Literature DB >> 6805466

Evolutionary significance of the renal excretion of transferrin half-molecule fragments.

J Williams, S A Grace, J M Williams.   

Abstract

It is generally thought that the duplicated structure of serum transferrin in vertebrates arose by gene duplication and fusion from a small ancestral protein. We have found that the isolated domains of transferrin are rapidly lost from the bloodstream via the kidneys. Therefore we suggest that the ancestral transferrin was not a serum protein or, alternatively, that it was not as small as the half-molecule.

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Year:  1982        PMID： 6805466      PMCID： PMC1163659          DOI： 10.1042/bj2010417

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

1.  Studies of the binding of different iron donors to human serum transferrin and isolation of iron-binding fragments from the N- and C-terminal regions of the protein.

Authors:  R W Evans; J Williams
Journal:  Biochem J       Date:  1978-08-01       Impact factor: 3.857

2.  Molecular weight and subunit structure of hagfish transferrin.

Authors:  P Aisen; A Leibman; C L Sia
Journal:  Biochemistry       Date:  1972-08-29       Impact factor: 3.162

3.  Physical evidence for transferrins as single polypeptide chains.

Authors:  F C Greene; R E Feeney
Journal:  Biochemistry       Date:  1968-04       Impact factor: 3.162

4.  Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors:  G Mancini; A O Carbonara; J F Heremans
Journal:  Immunochemistry       Date:  1965-09

5.  Vertebrae transferrins. Molecular weights, chemical compositions, and iron-binding studies.

Authors:  R M Palmour; H E Sutton
Journal:  Biochemistry       Date:  1971-10-26       Impact factor: 3.162

Review 6.  Iron transport and storage proteins.

Authors:  P Aisen; I Listowsky
Journal:  Annu Rev Biochem       Date:  1980       Impact factor: 23.643

7.  Evidence for the bilobal nature of diferric rabbit plasma transferrin.

Authors:  B Gorinsky; C Horsburgh; P F Lindley; D S Moss; M Parkar; J L Watson
Journal:  Nature       Date:  1979-09-13       Impact factor: 49.962

8.  Analysis of structural similarities between brain Thy-1 antigen and immunoglobulin domains. Evidence for an evolutionary relationship and a hypothesis for its functional significance.

Authors:  F E Cohen; J Novotný; M J Sternberg; D G Campbell; A F Williams
Journal:  Biochem J       Date:  1981-04-01       Impact factor: 3.857

9.  Iron-binding fragments from the carboxyl-terminal region of hen ovotransferrin.

Authors:  J Williams
Journal:  Biochem J       Date:  1975-07       Impact factor: 3.857

10.  The formation of iron-binding fragments of hen ovotransferrin by limited proteolysis.

Authors:  J Williams
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857
  10 in total
  7 in total

1.  The dimerization of half-molecule fragments of transferrin.

Authors:  J Williams; K Moreton
Journal:  Biochem J       Date:  1988-05-01       Impact factor: 3.857

2.  Occupancy of the iron binding sites of human transferrin.

Authors:  H A Huebers; B Josephson; E Huebers; E Csiba; C A Finch
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

3.  Large cooperativity in the removal of iron from transferrin at physiological temperature and chloride ion concentration.

Authors:  David H Hamilton; Isabelle Turcot; Alain Stintzi; Kenneth N Raymond
Journal:  J Biol Inorg Chem       Date:  2004-10-29       Impact factor: 3.358

Review 4.  Lactoferrin: from the structure to the functional orchestration of iron homeostasis.

Authors:  Giusi Ianiro; Luigi Rosa; Maria Carmela Bonaccorsi di Patti; Piera Valenti; Giovanni Musci; Antimo Cutone
Journal:  Biometals       Date:  2022-10-10       Impact factor: 3.378

5.  On the evolutionary significance and metal-binding characteristics of a monolobal transferrin from Ciona intestinalis.

Authors:  Arthur D Tinoco; Cynthia W Peterson; Baldo Lucchese; Robert P Doyle; Ann M Valentine
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-20       Impact factor: 11.205

6.  Evolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesis.

Authors:  Anne B Mason; Gregory L Judson; Maria Cristina Bravo; Andrew Edelstein; Shaina L Byrne; Nicholas G James; Eric D Roush; Carol A Fierke; Cedric E Bobst; Igor A Kaltashov; Margaret A Daughtery
Journal:  Biochemistry       Date:  2008-08-20       Impact factor: 3.162

7.  Polymorphism, selection and tandem duplication of transferrin genes in Atlantic cod (Gadus morhua)--conserved synteny between fish monolobal and tetrapod bilobal transferrin loci.

Authors:  Øivind Andersen; Maria Cristina De Rosa; Davide Pirolli; Ave Tooming-Klunderud; Petra E Petersen; Carl André
Journal:  BMC Genet       Date:  2011-05-25       Impact factor: 2.797
  7 in total

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