| Literature DB >> 6803388 |
J Benveniste, M Chignard, J P Le Couedic, B B Vargaftig.
Abstract
The role of phospholipase A2 (PLA2) in the formation of platelet-activating factor (PAF-acether) by rabbit platelets is supported by several pieces of evidence. First, the release of PAF-acether was accompanied by that of its deacetylated analog, lyso-PAF-acether. Second, EDTA, EGTA, db-AMPc, p'-bromophenacylbromide and 874 CB, which, in spite of their structural diversity, are all PLA2 blockers, inhibited the release of both PAF-acether and of the lyso-compound. Third, addition of hog pancreas PLA2 to platelets as well as platelet lysis resulted in the release of lyso-PAF-acether, thus mimicking the metabolic events initiating formation of PAF-acether. These results indicate that PLA2 activation triggers both the second and the third pathway of platelet activation.Entities:
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Year: 1982 PMID： 6803388 DOI： 10.1016/0049-3848(82)90128-1
Source DB: PubMed Journal: Thromb Res ISSN： 0049-3848 Impact factor: 3.944