Literature DB >> 6801200

The effect of carbidopa and benserazide on human plasma 5-hydroxytryptophan levels.

S N Young, S Gauthier, G Chouinard, G M Anderson, W C Purdy.   

Abstract

Peripheral aromatic amino acid decarboxylase inhibitors increase human plasma 5-hydroxytryptophan (5-HTP) levels. However the 5-HTP, which is synthesized in the intestine, is not present in a sufficient quantity to influence brain 5-HT to any significant degree. Thus, peripheral decarboxylase inhibitors are unlikely to affect brain 5-HT function via 5-HTP which is synthesized peripherally.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 6801200     DOI： 10.1007/BF01243522

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  11 in total

1.  The determination of 5-hydroxytryptophan and its metabolites in plasma following administration to man.

Authors:  M H Joseph; H F Baker
Journal:  Clin Chim Acta       Date:  1976-10-01       Impact factor: 3.786

2.  A controlled study of tryptophan-benserazide in schizophrenia.

Authors:  Q Chouinard; L Annable; S N Young; T L Sourkes
Journal:  Commun Psychopharmacol       Date:  1978

3.  Suppression of noradrenaline synthesis in sympathetic nerves by carbidopa, an inhibitor of peripheral dopa decarboxylase.

Authors:  R J Wurtman; C J Watkins
Journal:  Nature       Date:  1977-01-06       Impact factor: 49.962

4.  Inhibition of human and rat hepatic aminotransferase activity with L-3,4-dihydroxyphenylalanine by inhibitors of peripheral aromatic amino acid decarboxylase.

Authors:  M J Waterhouse; Y C Chia; G J Lees
Journal:  Mol Pharmacol       Date:  1979-01       Impact factor: 4.436

5.  Liquid chromatographic-fluorometric system for the determination of indoles in physiological samples.

Authors:  G M Anderson; W C Purdy
Journal:  Anal Chem       Date:  1979-02       Impact factor: 6.986

6.  Attempts to measure endogenous levels of dopa and 5-hydroxytryptophan in rat brain.

Authors:  M Lindqvist; W Kehr; A Carlsson
Journal:  J Neural Transm       Date:  1975       Impact factor: 3.575

7.  Brain and peripheral metabolism of 5-hydroxytryptophan-14C following peripheral decarboxylase inhibition.

Authors:  J J Warsh; H C Stancer
Journal:  J Pharmacol Exp Ther       Date:  1976-06       Impact factor: 4.030

8.  Formation of 5-hydroxykynurenine and 5-hydroxykynurenamine from 5-hydroxytryptophan in rabbit small intestine.

Authors:  M Fujiwara; M Shibata; Y Nomiyama; T Sugimoto; F Hirata; T Tokuyama; S Senoh; O Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

9.  Serum levels of 5-hydroxyindole derivates after administration of L-5-hydroxytryptophan ethyl ester.

Authors:  J Korf; J B Sebens; K Venema; H M van Praag
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1976-09

10.  Radioenzymatic assay of DOPA (3,4-dihydroxyphenylalanine).

Authors:  G A Johnson; J M Gren; R Kupiecki
Journal:  Clin Chem       Date:  1978-11       Impact factor: 8.327
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.