Literature DB >> 1086173

The determination of 5-hydroxytryptophan and its metabolites in plasma following administration to man.

M H Joseph, H F Baker.   

Abstract

The estimation of 5-hydroxytryptophan and its metabolites 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in plasma is described. The method is based on solvent extraction and the use of a liquid cation exchange reagent to separate 5-hydroxytryptamine and 5-hydroxytryptophan. The 5-hydroxyindoles are determined fluorimetrically following derivatisation with o-phthalaldehyde in strong acid. Data on the specificity and linearity of the method are presented. The time course of plasma 5-hydroxyindoles after oral administration of 5-hydroxytryptophan is studied in two subjects as an example of the application of the method and of its possible role in monitoring the plasma levels in therapy or in provocative tests.

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Year:  1976        PMID： 1086173     DOI： 10.1016/0009-8981(76)90043-7

Source DB:  PubMed          Journal:  Clin Chim Acta        ISSN： 0009-8981            Impact factor:   3.786


  8 in total

1.  Brain tryptophan metabolism on the 5-hydroxytryptamine and kynurenine pathways in a strain of rats with a deficiency in platelet 5-HT.

Authors:  M H Joseph
Journal:  Br J Pharmacol       Date:  1978-07       Impact factor: 8.739

2.  Dose-dependent dual action of kynurenine, a tryptophan metabolite, on the turnover of 5-hydroxytryptamine [proceedings].

Authors:  S E Gould; S L Handley
Journal:  Br J Pharmacol       Date:  1978-06       Impact factor: 8.739

3.  Brain tryptophan metabolism in schizophrenia: a post mortem study of metabolites of the serotonin and kynurenine pathways in schizophrenic and control subjects.

Authors:  M H Jospeh; H F Baker; T J Crow; G J Riley; D Risby
Journal:  Psychopharmacology (Berl)       Date:  1979-04-25       Impact factor: 4.530

4.  Increase of urinary 5-hydroxyindoleacetic acid excretion but not serum chromogranin A following over-the-counter 5-hydroxytryptophan intake.

Authors:  Tisha Joy; Grace Walsh; Sonya Tokmakejian; Stan Hm Van Uum
Journal:  Can J Gastroenterol       Date:  2008-01       Impact factor: 3.522

5.  Differential changes of blood and urinary indoleamines following intravenous ethanol administration in alcoholic and non-drinker women.

Authors:  C M Banki; M Vojnik
Journal:  J Neural Transm       Date:  1978       Impact factor: 3.575

6.  Development of tolerance to the wet-dog shake behaviour but not the increase in seizure threshold induced by L-5-hydroxytryptophan during continued treatment in rats.

Authors:  S R Pagliusi; W Löscher
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

7.  Effect of intravenous infusion of amitriptyline on total blood serotonin content.

Authors:  C M Banki; M Vojnik
Journal:  Eur J Clin Pharmacol       Date:  1978-06-19       Impact factor: 2.953

8.  The effect of carbidopa and benserazide on human plasma 5-hydroxytryptophan levels.

Authors:  S N Young; S Gauthier; G Chouinard; G M Anderson; W C Purdy
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575
  8 in total

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