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Literature DB >> 6796651

5-S-Cysteinyldopa in ganglion stellatum.

C Fehling, C Hansson, J Poulsen, H Rorsman, E Rosengren.

Abstract

5-S-Cysteinyldopa, an amino acid formed by nucleophilic addition of cysteine to dopaquinone, has been detected in the ganglion stellatum of the cow in amounts varying between 21 and 35 ng/g ganglionic tissue. Dopa was present in slightly higher quantities. Cysteinyldopa has previously been regarded as a substance unique for the melanocytes, where it forms melanin after oxidation and polymerization. At present only hypothetical explanations of our finding can be offered. The content of 5-S-cysteinyldopa in ganglion stellatum may be the result of dopa oxidation in ganglionic cells. An uptake mechanism for circulating cysteinyldopa may exist. Localization of cysteinyldopa to aberrant melanocytes or to aged SIF-cells in the ganglia should also be borne in mind.

Entities: Chemical Species

Mesh：

Substances：

Year: 1981 PMID： 6796651 DOI： 10.1007/BF01249607

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

11 in total

1. THE DISTRIBUTION OF DOPAMINE AND DOPA IN VARIOUS ANIMALS AND A METHOD FOR THEIR DETERMINATION IN DIVERSE BIOLOGICAL MATERIAL.

Authors: A H ANTON; D F SAYRE
Journal: J Pharmacol Exp Ther Date: 1964-09 Impact factor: 4.030

2. Fluorescence histochemical demonstration of dopa thioethers by condensation with gaseous formaldehyde.

Authors: G Agrup; A Björklund; B Falck; S Jacobsson; O Lindvall; H Rorsman; E Rosengren
Journal: Histochemistry Date: 1977-05-20

3. Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-Hydroxydopamine.

Authors: H Thoenen; J P Tranzer
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1968

4. A sensitive method for determination of 5-S-cysteinyldopa.

Authors: H Rorsman; A M Rosengren; E Rosengren
Journal: Acta Derm Venereol Date: 1973 Impact factor: 4.437

5. Cysteinyl dopa in human malignant melanoma.

Authors: A Björklund; B Falck; S Jacobsson; H Rorsman; A M Rosengren; E Rosengren
Journal: Acta Derm Venereol Date: 1972 Impact factor: 4.437

6. Model experiments on the molecular mechanism of action of 6-hydroxydopamine.

Authors: A Saner; H Thoenen
Journal: Mol Pharmacol Date: 1971-03 Impact factor: 4.436

7. Analysis of cysteinyldopas, dopa, dopamine, noradrenaline and adrenaline in serum and urine using high-performance liquid chromatography and electrochemical detection.

Authors: C Hansson; G Agrup; H Rorsman; A M Rosengren; E Rosengren; L E Edholm
Journal: J Chromatogr Date: 1979-01-01

5-S-Cysteinyldopa in ganglion stellatum.

1. THE DISTRIBUTION OF DOPAMINE AND DOPA IN VARIOUS ANIMALS AND A METHOD FOR THEIR DETERMINATION IN DIVERSE BIOLOGICAL MATERIAL.

2. Fluorescence histochemical demonstration of dopa thioethers by condensation with gaseous formaldehyde.

3. Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-Hydroxydopamine.

4. A sensitive method for determination of 5-S-cysteinyldopa.

5. Cysteinyl dopa in human malignant melanoma.

6. Model experiments on the molecular mechanism of action of 6-hydroxydopamine.

7. Analysis of cysteinyldopas, dopa, dopamine, noradrenaline and adrenaline in serum and urine using high-performance liquid chromatography and electrochemical detection.

8. 5-hydroxydopa, a new compound in the Raper-Mason scheme of melanogenesis.

9. 5-S-cysteinyldopa, dopa, and dopamine in the kidney and some other tissues.

10. 5-S-cysteinyldopa in the plasma of melanoma patients and the renal clearance of this amino acid.

1. Detection of 5-S-cysteinyldopamine in human brain.

2. Evidence of dopa in the nerves of sea anemones.