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Literature DB >> 6792318

Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains.

N Ishii, C N Baxevanis, Z A Nagy, J Klein.

Abstract

T cells from strains responder to the antigen poly(Glu40 Ala60) (GA) were depleted of alloreactive cells by bromo-deoxyuridine and light treatment, and were subsequently primed in vitro in GA presented by allogeneic macrophages from nonresponder strains. Antigen-specific secondary proliferative responses restricted by allogeneic Ia molecules of the macrophages were obtained in all strain combinations tested. These data indicate that Ir gene-controlled nonresponsiveness cannot be the result of a failure of antigen presentation.

Entities: Chemical

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Year: 1981 PMID： 6792318 PMCID： PMC2186446 DOI： 10.1084/jem.154.3.978

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

14 in total

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Authors: H Lemke; G J Hämmerling; U Hämmerling
Journal: Immunol Rev Date: 1979 Impact factor: 12.988

2. Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.

Authors: H von Boehmer; W Haas; N K Jerne
Journal: Proc Natl Acad Sci U S A Date: 1978-05 Impact factor: 11.205

3. Nature of T cell-macrophage interaction in helper cell induction in vitro. III. Responsiveness of T cells differentiating in irradiation or allophenic chimeras depends on the genotype of the host.

Authors: P Erb; P Vogt; T Matsunaga; A Rosenthal; M Feldmann
Journal: J Immunol Date: 1980-06 Impact factor: 5.422

Review 4. A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes.

Authors: B Benacerraf
Journal: J Immunol Date: 1978-06 Impact factor: 5.422

5. Genetic control of T-cell proliferative responses to poly(glu40ala60) and poly(glu51lys34tyr15): subregion-specific inhibition of the responses with monoclonal Ia antibodies.

Authors: C N Baxevanis; D Wernet; Z A Nagy; P H Maurer; J Klein
Journal: Immunogenetics Date: 1980 Impact factor: 2.846

6. Nature of the antigenic complex recognized by T lymphocytes: specific sensitization by antigens associated with allogeneic macrophages.

Authors: D W Thomas; E M Shevach
Journal: Proc Natl Acad Sci U S A Date: 1977-05 Impact factor: 11.205

7. The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.

Authors: D B Wilson; K F Lindahl; D H Wilson; J Sprent
Journal: J Exp Med Date: 1977-08-01 Impact factor: 14.307

8. The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.

Authors: J W Kappler; P Marrack
Journal: J Exp Med Date: 1978-12-01 Impact factor: 14.307

9. T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten.

Authors: C A Janeway; P D Murphy; J Kemp; H Wigzell
Journal: J Exp Med Date: 1978-04-01 Impact factor: 14.307

10. Gene complementation. Neither Ir-GLphi gene need be present in the proliferative T cell to generate an immune response to Poly(Glu55Lys36Phe9)n.

Authors: D L Longo; R H Schwartz
Journal: J Exp Med Date: 1980-06-01 Impact factor: 14.307

27 in total

1. Preferential restriction of minor alloantigen-specific suppressor T cells to I-E rather than I-A molecules.

Authors: N K Nanda
Journal: Immunology Date: 1989-10 Impact factor: 7.397

2. Interaction between a "processed" ovalbumin peptide and Ia molecules.

Authors: S Buus; S Colon; C Smith; J H Freed; C Miles; H M Grey
Journal: Proc Natl Acad Sci U S A Date: 1986-06 Impact factor: 11.205

3. Human allospecific TLCs generated against HLA antigens associated with DR1 through DRw8. II. Population analyses and blocking studies with monoclonal antibodies.

Authors: S Rosen-Bronson; A H Johnson; R J Hartzman; D D Eckels
Journal: Immunogenetics Date: 1986 Impact factor: 2.846

4. Age-dependent appearance of non-major histocompatibility complex-restricted helper T cells.

Authors: C Russo; E P Cherniack; A Wali; M E Weksler
Journal: Proc Natl Acad Sci U S A Date: 1993-12-15 Impact factor: 11.205

5. Structural analysis of insulin determinants seen by T cells directed by H-2 genes.

Authors: J Talmon; G Ranghino; A Yonath; I R Cohen
Journal: Immunogenetics Date: 1983 Impact factor: 2.846

Review 6. Mononuclear phagocytes: phenotype and function.

Authors: D L Thiele; P E Lipsky
Journal: Surv Immunol Res Date: 1984

7. Molecular events in the processing of avidin by antigen-presenting cells (APC). III. Activation of T-lymphocyte lines and H-2 restriction are mediated by processed avidin associated with I-region gene products.

Authors: A Friedman; R Zerubavel; C Gitler; I R Cohen
Journal: Immunogenetics Date: 1983 Impact factor: 2.846

8. Selection of H-2 molecules for the context of antigen recognition by T lymphocytes.

Authors: N Ishii; C N Baxevanis; Z A Nagy; J Klein
Journal: Immunogenetics Date: 1981 Impact factor: 2.846

9. Specific allogeneic help by T lymphocytes from patients with systemic lupus erythematosus.

Authors: M K Hari Kumar; R A Knight; M L Snaith
Journal: Clin Exp Immunol Date: 1984-10 Impact factor: 4.330

10. Mechanisms of genetic control of immune responses. I. Evidence for distinct multi-step helper T-cell pathways in cellular and humoral responses to GAT.

Authors: S D Miller; R W Melvold; C Waltenbaugh
Journal: Immunogenetics Date: 1984 Impact factor: 2.846