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Literature DB >> 6788887

Genetic studies in NZB mice. V. Recombinant inbred lines demonstrate that separate genes control autoimmune phenotype.

E S Raveche, E A Novotny, C T Hansen, J H Tjio, A D Steinberg.

Abstract

The genetic basis for autoimmunity in NZB mice has been investigated through analysis of recombinant inbred lines produced by mating NZB mice with two different non-autoimmune strains. Several genes (at least six) were found to be necessary for the production of eight traits characteristic of the NZB mice that were studied. No fundamental genetic defect (an "autoimmunity gene") was identified that could give rise to the various autoimmune traits studied. This study strongly suggests that NZB disease results from the actions of several separate genes that together result in the characteristic manifestations of autoimmunity.

Entities: Disease Species

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Year: 1981 PMID： 6788887 PMCID： PMC2186161 DOI： 10.1084/jem.153.5.1187

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

24 in total

1. Host-gene control of C-type RNA tumor virus: inheritance of the group-specific antigen of murine leukemia virus.

Authors: B A Taylor; H Meier; D D Myers
Journal: Proc Natl Acad Sci U S A Date: 1971-12 Impact factor: 11.205

Review 2. The pathogenesis of autoimmunity in New Zealand black mice.

Authors: N Talal; A D Steinberg
Journal: Curr Top Microbiol Immunol Date: 1974 Impact factor: 4.291

3. Study of autoimmune disease in New Zealand mice. I. Genetic features and natural history of NZB, NZY and NZW strains and NZB-NZW hybrids.

Authors: I M Braverman
Journal: J Invest Dermatol Date: 1968-06 Impact factor: 8.551

10. Ability of the xid gene to prevent autoimmunity in (NZB X NZW)F1 mice during the course of their natural history, after polyclonal stimulation, or following immunization with DNA.

Authors: B J Steinberg; P A Smathers; K Frederiksen; A D Steinberg
Journal: J Clin Invest Date: 1982-09 Impact factor: 14.808

Genetic studies in NZB mice. V. Recombinant inbred lines demonstrate that separate genes control autoimmune phenotype.

1. Host-gene control of C-type RNA tumor virus: inheritance of the group-specific antigen of murine leukemia virus.

Review 2. The pathogenesis of autoimmunity in New Zealand black mice.

3. Study of autoimmune disease in New Zealand mice. I. Genetic features and natural history of NZB, NZY and NZW strains and NZB-NZW hybrids.

4. Genetic control of spontaneous and induced antierythrocyte autoantibody production in mice.

5. The genetic basis of autoimmunity in NZB mice studied by progeny-testing.

6. Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes.

7. Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

8. Genetic investigations of autoimmune disease in mice.

9. The characteristics of F1 and backcross hybrids between "high leukaemia" (AKR) and "autoimmune" (NZB) mouse strains.

10. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.

1. Proliferation of CD3+ B220- single-positive normal T cells was suppressed in B-cell-deficient lpr mice.

2. Genetic analysis of the imperfect association of H-2 haplotype with lupus-like autoimmune disease.

3. Requirement for increased IL-10 in the development of B-1 lymphoproliferative disease in a murine model of CLL.

Review 4. Differential gene expression in autoimmune mice.

Review 5. Mechanisms of genetic control of murine systemic lupus erythematosus.

6. Genetic regulation of erythrocyte autoantibody production in New Zealand black mice.

Review 7. Genes and genetic mechanism in systemic lupus.

Review 8. Autoimmune diseases: immunopathology and etiopathogenesis.

9. Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice.

10. Ability of the xid gene to prevent autoimmunity in (NZB X NZW)F1 mice during the course of their natural history, after polyclonal stimulation, or following immunization with DNA.