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Literature DB >> 6788878

Lyt-2-/Lyt 3- variants of a cloned cytolytic T cell line lack an antigen receptor functional in cytolysis.

D P Dialynas, M R Loken, A L Glasebrook, F W Fitch.

Abstract

To investigate the role of Lyt-2 and Thy-1 in cytolysis, we have generated, by ethyl methanesulfonate mutagenesis and selection, variants of the cloned cytolytic T lymphocyte line L3 that specifically lack either Lyt-2 or Thy-1. An analysis of these variants indicates that neither Lyt-2 nor Lyt-3 is responsible for the lethal hit, but suggests that Lyt-2 and/or Lyt-3 are required for an antigen receptor functional in cytolysis. The data also suggest that the expression of Lyt-3 on the cell surface is not independent of the expression of Lyt-2. Finally the data indicate the Thy-1 plays no role in cytolysis.

Entities: Chemical Gene

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Year: 1981 PMID： 6788878 PMCID： PMC2186095 DOI： 10.1084/jem.153.3.595

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

22 in total

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Journal: J Exp Med Date: 1976-08-01 Impact factor: 14.307

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19 in total

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Authors: Giovanni D'Angelo; Libera Prencipe; Luisa Iodice; Galina Beznoussenko; Marco Savarese; Pierfrancesco Marra; Giuseppe Di Tullio; Gianluca Martire; Maria Antonietta De Matteis; Stefano Bonatti
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Journal: Immunology Date: 1986-10 Impact factor: 7.397