Literature DB >> 6787704

Thyrotropin-releasing hormone improves cardiovascular function in experimental endotoxic and hemorrhagic shock.

J W Holaday, R J D'Amato, A I Faden.   

Abstract

Thyrotropin-releasing hormone significantly improved cardiovascular function when it was injected intravenously into conscious rats subjected to experimental endotoxic or hemorrhagic shock. Because thyrotropin-releasing hormone appears to be a "physiologic: opiate antagonist without effects on pain responsiveness, it may provide therapeutic benefits in the treatment of shock or acute hypotension.

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Year:  1981        PMID： 6787704     DOI： 10.1126/science.6787704

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  15 in total

1.  Three approaches to pathophysiology of shock.

Authors:  M Miyazaki; S Yokono; C Okuda; T Mizobe
Journal:  J Anesth       Date:  1988-09-01       Impact factor: 2.078

2.  Pressor effects of thyrotrophin releasing hormone during thyroid function testing.

Authors:  E Rosenthal; Y C Najm; M N Maisey; P V Curry
Journal:  Br Med J (Clin Res Ed)       Date:  1987-03-28

3.  Thyrotropin-releasing hormone (TRH) counteracts neuronal damage induced by a substance P antagonist.

Authors:  J Freedman; T Hökfelt; G Jonsson; C Post
Journal:  Exp Brain Res       Date:  1986       Impact factor: 1.972

4.  Immunohistochemical and behavioral analysis of spinal lesions induced by a substance P antagonist and protection by thyrotropin releasing hormone.

Authors:  J Freedman; T Hökfelt; C Post; E Brodin; E Sundström; G Jonsson; L Terenius; S Leander; J A Fischer; A Verhofstad
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

5.  Effects of thyrotropin-releasing hormone on cardiovascular function in dogs with hemorrhagic shock.

Authors:  D Y Hu; X D He; H S Chen; S H Liao; C G Fan; L Li
Journal:  J Tongji Med Univ       Date:  1988

6.  Multiple opioid receptors in endotoxic shock: evidence for delta involvement and mu-delta interactions in vivo.

Authors:  R D'Amato; J W Holaday
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

7.  Analogs of thyrotropin-releasing hormone (TRH): receptor affinities in brains, spinal cords, and pituitaries of different species.

Authors:  N A Sharif; Z P To; R L Whiting
Journal:  Neurochem Res       Date:  1991-02       Impact factor: 3.996

8.  Is the Mg(2+)-ATP-dependent proton pumping activity of the synaptic vesicles a factor involved in the cerebral hypoxia?

Authors:  G Benzi; A Gorini; B Ghigini; A Moretti; F Dagani; R F Villa
Journal:  Neurochem Res       Date:  1996-01       Impact factor: 3.996

9.  The effects of TRH analogues on cerebral ischaemia produced by middle cerebral artery occlusion in the rat.

Authors:  J Shrewsbury-Gee; R H Lye; A Latham; P Slater
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

10.  Effects of water-immersion-induced stress and intraperitoneal administration of brain-gut peptides upon immunoreactive thyrotropin-releasing hormone and prostaglandin E2 concentrations in the rat stomach.

Authors:  Y Maeda; K Morise; K Kusugami; K Uchida; A Furusawa; H Kaneko; K Nakada; T Mitsuma; F Kurimoto
Journal:  Gastroenterol Jpn       Date:  1991-08
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