Literature DB >> 2420632

Thyrotropin-releasing hormone (TRH) counteracts neuronal damage induced by a substance P antagonist.

J Freedman, T Hökfelt, G Jonsson, C Post.   

Abstract

Intrathecal administration of the substance P antagonist Spantide caused marked necrotic changes of the gray matter of the spinal cord extending several segments from the injection site. Intravenous treatment with several doses of thyrotropin releasing hormone before and after Spantide injection completely prevented the necrotic lesion.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 2420632     DOI： 10.1007/bf00237413

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  13 in total

1.  Similar motor effects of 5-HT and TRH in rats following chronic spinal transection and 5.7-dihydroxytryptamine injection.

Authors:  H Barbeau; P Bédard
Journal:  Neuropharmacology       Date:  1981-05       Impact factor: 5.250

Review 2.  Substance P.

Authors:  B Pernow
Journal:  Pharmacol Rev       Date:  1983-06       Impact factor: 25.468

3.  Immunohistochemical support for three putative transmitters in one neuron: coexistence of 5-hydroxytryptamine, substance P- and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cord.

Authors:  O Johansson; T Hökfelt; B Pernow; S L Jeffcoate; N White; H W Steinbusch; A A Verhofstad; P C Emson; E Spindel
Journal:  Neuroscience       Date:  1981       Impact factor: 3.590

4.  Thyrotropin-releasing hormone (TRH) improves survival in anaphylactic shock: a central effect mediated by the sympatho-adrenomedullary beta-adrenoceptive system.

Authors:  S Amir; M Harel; A Schachar
Journal:  Brain Res       Date:  1984-04-30       Impact factor: 3.252

5.  Chronic catheterization of the spinal subarachnoid space.

Authors:  T L Yaksh; T A Rudy
Journal:  Physiol Behav       Date:  1976-12

6.  Antinociceptive and neurotoxic actions of substance P analogues in the rat's spinal cord after intrathecal administration.

Authors:  C Post; I Paulsson
Journal:  Neurosci Lett       Date:  1985-06-12       Impact factor: 3.046

7.  Thyrotropin-releasing hormone improves neurologic recovery after spinal trauma in cats.

Authors:  A I Faden; T P Jacobs; J W Holaday
Journal:  N Engl J Med       Date:  1981-10-29       Impact factor: 91.245

8.  Immunohistochemical evidence for a "neurotoxic" action of (D-Pro2, D-Trp7,9)-substance P, an analogue with substance P antagonistic activity.

Authors:  T Hökfelt; S Vincent; L Hellsten; S Rosell; K Folkers; K Markey; M Goldstein; C Cuello
Journal:  Acta Physiol Scand       Date:  1981-12

9.  The behavioural effects of intrathecally administered [D-PRO2, D-TRP7,9]-substance P, an analogue with presumed antagonist actions, in the rat.

Authors:  R E Rodriguez; T E Salt; P M Cahusac; R G Hill
Journal:  Neuropharmacology       Date:  1983-02       Impact factor: 5.250

10.  Thyrotropin-releasing hormone improves cardiovascular function in experimental endotoxic and hemorrhagic shock.

Authors:  J W Holaday; R J D'Amato; A I Faden
Journal:  Science       Date:  1981-07-10       Impact factor: 47.728
View more
  5 in total

1.  Proceedings of the British Pharmacological Society. Bristol, 5-7th April. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1989-07       Impact factor: 8.739

2.  Immunohistochemical and behavioral analysis of spinal lesions induced by a substance P antagonist and protection by thyrotropin releasing hormone.

Authors:  J Freedman; T Hökfelt; C Post; E Brodin; E Sundström; G Jonsson; L Terenius; S Leander; J A Fischer; A Verhofstad
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

3.  A novel substance P binding site in rat brain regions modulates TRH receptor binding.

Authors:  N A Sharif
Journal:  Neurochem Res       Date:  1990-10       Impact factor: 3.996

4.  Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists.

Authors:  B F Cox; R L Schelper; F M Faraci; M J Brody
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

5.  Pharmacological and biochemical comparison of thyrotropin releasing hormone (TRH) and di-methyl proline-TRH on pituitary GH3 cells.

Authors:  A M McDermott; G P Wilkin; S L Dickinson
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.