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Literature DB >> 6787164

A monoclonal antibody that recognizes B cells and B cell precursors in mice.

Abstract

The monoclonal antibody, RA3-2C2, appears to be specific for cells within the B cell lineage. This antibody does not recognize thymocytes, peripheral T cells, or nonlymphoid hematopoietic cells in the spleen or bone marrow. Nor does it recognize the pluripotent hematopoietic stem cells, the spleen colony-forming unit, All sIg+ B cells and most plasma cells are RA3-2C2+. In addition, approximately 20% of nucleated bone marrow cells are RA3-2C2+ but sIg-. This population contains B cell precursors that can give rise to sIg+ cells within 2 d in vitro.

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Year: 1981 PMID： 6787164 PMCID： PMC2186081 DOI： 10.1084/jem.153.2.269

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

20 in total

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Review 3. The class of surface immunoglobulin on virgin and memory B lymphocytes.

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Authors: E C Butcher; R G Scollay; I L Weissman
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5. Mouse bone marrow lymphocytes and their differentiation.

Authors: J E Ryser; P Vassalli
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6. Differentiation of lymphocytes in mouse bone marrow. II. Kinetics of maturation and renewal of antiglobulin-binding cells studied by double labeling.

Authors: D G Osmond; G J Nossal
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Review 6. The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases.

Authors: Irving L Weissman; Judith A Shizuru
Journal: Blood Date: 2008-11-01 Impact factor: 22.113

A monoclonal antibody that recognizes B cells and B cell precursors in mice.

1. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.

2. Lymphosarcoma cell growth is selectively inhibited by B lymphocyte mitogens: LPS, dextran sulfate and PPD.

Review 3. The class of surface immunoglobulin on virgin and memory B lymphocytes.

4. Direct fluorescent labeling of cells with fluorescein or rhodamine isothiocyanate. II. Potential application to studies of lymphocyte migration and maturation.

5. Mouse bone marrow lymphocytes and their differentiation.

6. Differentiation of lymphocytes in mouse bone marrow. II. Kinetics of maturation and renewal of antiglobulin-binding cells studied by double labeling.

7. Ly-4.2: a cell membrane alloantigen of murine B lymphocytes. I. Population studies.

8. Abelson murine leukemia virus-induced tumors elicit antibodies against a host cell protein, P50.

9. Immunization of dissociated spleen cell cultures from normal mice.

10. A quantitative assay for the progenitors of bone marrow-associated lymphocytes.

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