Literature DB >> 6785302

Prothrombin activation by a metalloprotease from Staphylococcus aureus.

Z Wegrzynowicz, P B Heczko, G R Drapeau, J Jeljaszewicz, G Pulverer.   

Abstract

Formation of thrombin during incubation of purified bovine prothrombin with purified staphylococcal metalloprotease has been investigated. Thrombin activity was estimated by examination of clotting time and by digestion of a synthetic substrate, Chromozym TH. The metalloprotease caused direct activation of prothrombin which was inhibited by the addition of ethylenediaminetetraacetic acid. Metalloprotease produced by some strains of Staphylococcus aureus may simulate staphylocoagulase activity.

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Year:  1980        PMID： 6785302      PMCID： PMC273542          DOI： 10.1128/jcm.12.2.138-139.1980

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  11 in total

1.  Prothrombin activation induced by Ecarin - a prothrombin converting enzyme from Echis carinatus venom.

Authors:  F Kornalik; B Blombäck
Journal:  Thromb Res       Date:  1975-01       Impact factor: 3.944

2.  Occurrence of an extracellular serineproteinase among Staphylococcus aureus strains.

Authors:  A Björklind; S Arvidson
Journal:  Acta Pathol Microbiol Scand B       Date:  1977-08

3.  The nature of clotting and fibrinolytic activities of Bacteroids melaninogenicus.

Authors:  Z Wegrzynowicz; H J Ko; G Pulverer; J Jeljaszewicz
Journal:  Zentralbl Bakteriol Orig A       Date:  1978-01

4.  Studies on extracellular proteolytic enzymes from Staphylococcus aureus. II. Isolation and characterization of an EDTA-sensitive protease.

Authors:  S Arvidson
Journal:  Biochim Biophys Acta       Date:  1973-03-15

5.  Staphylococcus epidermidis, and emerging pathogen.

Authors:  J T Parisi
Journal:  Mo Med       Date:  1973-04

6.  Modified method for the preparation of purified bovine prothrombin of high specific activity.

Authors:  O P Malhotra; J R Carter
Journal:  Thromb Diath Haemorrh       Date:  1968-03-31

7.  Pseudocoagulase activity of staphylococci.

Authors:  Z Wegrzynowicz; P B Heczko; J Jeljaszewicz; M Neugebauer; G Pulverer
Journal:  J Clin Microbiol       Date:  1979-01       Impact factor: 5.948

8.  Role of metalloprotease in activation of the precursor of staphylococcal protease.

Authors:  G R Drapeau
Journal:  J Bacteriol       Date:  1978-11       Impact factor: 3.490

9.  Staphylococcal protease: a proteolytic enzyme specific for glutamoyl bonds.

Authors:  J Houmard; G R Drapeau
Journal:  Proc Natl Acad Sci U S A       Date:  1972-12       Impact factor: 11.205

10.  Peptocoagulase: clotting factor produced by bovine strains of Peptococcus indolicus.

Authors:  L M Switalski; O Schwam; C J Smyth; T Wadström
Journal:  J Clin Microbiol       Date:  1978-04       Impact factor: 5.948
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  12 in total

1.  Activation of blood coagulation factor IX by gingipains R, arginine-specific cysteine proteinases from Porphyromonas gingivalis.

Authors:  T Imamura; S Tanase; T Hamamoto; J Potempa; J Travis
Journal:  Biochem J       Date:  2001-01-15       Impact factor: 3.857

2.  Two allelic forms of the aureolysin gene (aur) within Staphylococcus aureus.

Authors:  A Sabat; K Kosowska; K Poulsen; A Kasprowicz; A Sekowska; B van Den Burg; J Travis; J Potempa
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

3.  Staphylococcal proteases aid in evasion of the human complement system.

Authors:  Monika Jusko; Jan Potempa; Tomasz Kantyka; Ewa Bielecka; Halie K Miller; Magdalena Kalinska; Grzegorz Dubin; Peter Garred; Lindsey N Shaw; Anna M Blom
Journal:  J Innate Immun       Date:  2013-07-03       Impact factor: 7.349

4.  Vibrio vulnificus secretes a broad-specificity metalloprotease capable of interfering with blood homeostasis through prothrombin activation and fibrinolysis.

Authors:  Alan K Chang; Hyo Young Kim; Jung Eun Park; Pankaj Acharya; Il-Seon Park; Seong Myeong Yoon; Ho Jin You; Kyung-Soo Hahm; Jong Kun Park; Jung Sup Lee
Journal:  J Bacteriol       Date:  2005-10       Impact factor: 3.490

5.  Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant-anticoagulant equilibrium toward thrombosis.

Authors:  Giulia Pontarollo; Laura Acquasaliente; Daniele Peterle; Roberta Frasson; Ilaria Artusi; Vincenzo De Filippis
Journal:  J Biol Chem       Date:  2017-07-06       Impact factor: 5.157

6.  Molecular characterization of a novel Staphylococcus aureus serine protease operon.

Authors:  S B Reed; C A Wesson; L E Liou; W R Trumble; P M Schlievert; G A Bohach; K W Bayles
Journal:  Infect Immun       Date:  2001-03       Impact factor: 3.441

7.  Rapid and direct staphylocoagulase assay that uses a chromogenic substrate for identification of Staphylococcus aureus.

Authors:  W Engels; M A Kamps; C P van Boven
Journal:  J Clin Microbiol       Date:  1981-11       Impact factor: 5.948

8.  Incidence of the highly conserved fib gene and expression of the fibrinogen-binding (Fib) protein among clinical isolates of Staphylococcus aureus.

Authors:  M K Bodén Wästfelt; J I Flock
Journal:  J Clin Microbiol       Date:  1995-09       Impact factor: 5.948

9.  Extracellular proteases are key mediators of Staphylococcus aureus virulence via the global modulation of virulence-determinant stability.

Authors:  Stacey L Kolar; J Antonio Ibarra; Frances E Rivera; Joe M Mootz; Jessica E Davenport; Stanley M Stevens; Alexander R Horswill; Lindsey N Shaw
Journal:  Microbiologyopen       Date:  2012-12-11       Impact factor: 3.139

10.  Polymorphism, genetic exchange and intragenic recombination of the aureolysin gene among Staphylococcus aureus strains.

Authors:  Artur J Sabat; Benedykt Wladyka; Klaudia Kosowska-Shick; Hajo Grundmann; Jan Maarten van Dijl; Julia Kowal; Peter C Appelbaum; Adam Dubin; Waleria Hryniewicz
Journal:  BMC Microbiol       Date:  2008-07-29       Impact factor: 3.605
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