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Literature DB >> 6783058

The in vitro metabolism of ethinyloestradiol, mestranol and levonorgestrel by human jejunal mucosa.

D J Back, M Bates, A M Breckenridge, A Ellis, J M Hall, M Maciver, M L Orme, P H Rowe.

Abstract

1 Ethinyloestradiol was extensively metabolised in vitro by human jejunal mucosa to form ethinyloestradiol sulphate. 2 The amount of conjugation was directly related to the weight of biopsy tissue. 3 The degree of conjugation of mestranol and levonorgestrel was much lower than for ethinyloestradiol suggesting that the 17-position of the steroid nucleus is relatively inaccessible for conjugation. 4 No Phase I metabolism of ethinyloestradiol or levonorgestrel was apparent in the conditions used in these experiments.

Entities: Chemical Species

Keywords: Clinical Research; Contraception; Contraceptive Agents; Contraceptive Agents, Estrogen; Contraceptive Agents, Female; Contraceptive Agents, Progestin; Ethinyl Estradiol; Examinations And Diagnoses; Family Planning; In Vitro; Laboratory Examinations And Diagnoses; Laboratory Procedures; Mestranol; Metabolic Effects; Norgestrel; Research Methodology

Mesh：

Substances：

Year: 1981 PMID： 6783058 PMCID： PMC1401625 DOI： 10.1111/j.1365-2125.1981.tb00534.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

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