Literature DB >> 23960808

Loss of orally administered drugs in GI tract.

Yogeshkumar Nanasaheb Gavhane1, Adhikrao Vyankatrao Yadav.   

Abstract

The aim of this review is to provide a broad perspective on intestinal absorption and the impact of intestinal first-pass metabolism on both clearance and drug-drug interaction prediction along with its historical perspectives. The review also considers abilities to bridge the gap between the increasing amount of intestinal in vitro data and the importance of intestinal first-pass metabolism in vivo. The significance of efflux transporters on the intestinal absorption is also discussed.

Keywords:  CYP3A4; Cytochrome P450; Drug–drug interaction; Efflux transporters; Gut wall/mucosal enzymes; P-glycoprotein

Year:  2012        PMID： 23960808      PMCID： PMC3744959          DOI： 10.1016/j.jsps.2012.03.005

Source DB:  PubMed          Journal:  Saudi Pharm J        ISSN： 1319-0164            Impact factor:   4.330


  110 in total

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Authors:  J C Kolars; P Schmiedlin-Ren; J D Schuetz; C Fang; P B Watkins
Journal:  J Clin Invest       Date:  1992-11       Impact factor: 14.808

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Journal:  Genetics       Date:  1995-09       Impact factor: 4.562
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  26 in total

1.  The Effects of Pharmaceutical Excipients on Gastrointestinal Tract Metabolic Enzymes and Transporters-an Update.

Authors:  Wenpeng Zhang; Yanyan Li; Peng Zou; Man Wu; Zhenqing Zhang; Tao Zhang
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2.  Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine.

Authors:  Valérie Clermont; Alexia Grangeon; Azemi Barama; Jacques Turgeon; Michel Lallier; Jacques Malaise; Veronique Michaud
Journal:  Br J Clin Pharmacol       Date:  2019-04-13       Impact factor: 4.335

Review 3.  Opioid antagonists as potential therapeutics for ischemic stroke.

Authors:  Nadia Peyravian; Emre Dikici; Sapna Deo; Michal Toborek; Sylvia Daunert
Journal:  Prog Neurobiol       Date:  2019-08-06       Impact factor: 11.685

4.  Structure-property relations of a unique and systematic dataset of 19 isostructural multicomponent apremilast forms.

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Journal:  IUCrJ       Date:  2022-06-15       Impact factor: 5.588

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Journal:  Pharm Res       Date:  2017-10-23       Impact factor: 4.200

Review 6.  Oral drug absorption in pediatrics: the intestinal wall, its developmental changes and current tools for predictions.

Authors:  Jean-Marie Nicolas; François Bouzom; Chanteux Hugues; Anna-Lena Ungell
Journal:  Biopharm Drug Dispos       Date:  2017-02-06       Impact factor: 1.627

7.  A Steady-State Head-to-Head Pharmacokinetic Comparison of All FK-506 (Tacrolimus) Formulations (ASTCOFF): An Open-Label, Prospective, Randomized, Two-Arm, Three-Period Crossover Study.

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8.  Priming the body to receive the therapeutic agent to redefine treatment benefit/risk profile.

Authors:  Matthieu Germain; Marie-Edith Meyre; Laurence Poul; Marion Paolini; Céline Berjaud; Francis Mpambani; Maxime Bergere; Laurent Levy; Agnès Pottier
Journal:  Sci Rep       Date:  2018-03-19       Impact factor: 4.379

9.  Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15.

Authors:  Tamara Krajnović; Danijela Maksimović-Ivanić; Sanja Mijatović; Dijana Drača; Katharina Wolf; David Edeler; Ludger A Wessjohann; Goran N Kaluđerović
Journal:  Nanomaterials (Basel)       Date:  2018-05-12       Impact factor: 5.076

10.  Egg perivitelline fluid of the invasive snail Pomacea canaliculata affects mice gastrointestinal function and morphology.

Authors:  Matías Giglio; Cintia Garro; Enrique Caviedes-Vidal; Horacio Heras
Journal:  PeerJ       Date:  2018-10-29       Impact factor: 2.984
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