Literature DB >> 6781926

Role of lactone ring of aflatoxin B1 in toxicity and mutagenicity.

L S Lee, J J Dunn, A J DeLucca, A Ciegler.   

Abstract

Cleavage of the lactone ring of aflatoxin B1 results in a nonfluorescent compound that has greatly reduced biological activity. Mutagenicity, as measured by the Ames test, is reduced 450-fold compared to that of B1, and toxicity, as measured by the chick embryo test, is reduced 18-fold.

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Year:  1981        PMID： 6781926     DOI： 10.1007/BF01965543

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Action of weak bases upon aflatoxin B1 in contact with macromolecular reactants.

Authors:  A C Beckwith; R F Vesonder; A Ciegler
Journal:  J Agric Food Chem       Date:  1975 May-Jun       Impact factor: 5.279

2.  Synthesis and toxicity evaluation of aflatoxin P.

Authors:  G Buchi; D Spitzner; S Paglialunga; G N Wogan
Journal:  Life Sci       Date:  1973-10-16       Impact factor: 5.037

3.  [14C]Aflatoxin B1 as an indicator of toxin destruction during ammoniation of contaminated peanut meal.

Authors:  L S Lee; E J Conkerton; R L Ory; J W Bennett
Journal:  J Agric Food Chem       Date:  1979 May-Jun       Impact factor: 5.279

4.  Ammoniation of aflatoxin B1: isolation and identification of the major reaction product.

Authors:  L S Lee; J B Stanley; A F Cucullu; W A Pons; L A Goldblatt
Journal:  J Assoc Off Anal Chem       Date:  1974-05

5.  Aflatoxin detoxification: hydroxydihydro-aflatoxin B.

Authors:  A Ciegler; R E Peterson
Journal:  Appl Microbiol       Date:  1968-04

6.  Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.

Authors:  B N Ames; J Mccann; E Yamasaki
Journal:  Mutat Res       Date:  1975-12       Impact factor: 2.433

Review 7.  Mycotoxins: occurrence, chemistry, biological activity.

Authors:  A Ciegler
Journal:  Lloydia       Date:  1975 Jan-Feb

8.  Environmental degradation of the miticide cycloprate. 2. Metabolism by apples and oranges.

Authors:  G B Quistad; L E Staiger; D A Schooley
Journal:  J Agric Food Chem       Date:  1978 Jan-Feb       Impact factor: 5.279

9.  Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins.

Authors:  F C Wehner; P G Thiel; S J van Rensburg; I P Demasius
Journal:  Mutat Res       Date:  1978-11       Impact factor: 2.433

10.  Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential.

Authors:  J J Wong; D P Hsieh
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205
  10 in total
  18 in total

Review 1.  Microbial detoxification of mycotoxins.

Authors:  Susan P McCormick
Journal:  J Chem Ecol       Date:  2013-07-12       Impact factor: 2.626

2.  Biotransformation and detoxification of aflatoxin B1 by extracellular extract of Cladosporium uredinicola.

Authors:  Shuai Shao; Jun Cai; Xin Du; ChangGao Wang; JianGuo Lin; Jun Dai
Journal:  Food Sci Biotechnol       Date:  2016-12-31       Impact factor: 2.391

3.  Studies on toxigenic fungi in roasted foodstuff (salted seed) and halotolerant activity of emodin-producing Aspergillus wentii.

Authors:  H A Hasan
Journal:  Folia Microbiol (Praha)       Date:  1998       Impact factor: 2.099

4.  In vitro efficacy of Myxococcus fulvus ANSM068 to biotransform aflatoxin B₁.

Authors:  Shu Guan; Lihong Zhao; Qiugang Ma; Ting Zhou; Ning Wang; Xinxu Hu; Cheng Ji
Journal:  Int J Mol Sci       Date:  2010-10-20       Impact factor: 5.923

5.  Identification and characterization of two families of F420 H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation.

Authors:  Matthew C Taylor; Colin J Jackson; David B Tattersall; Nigel French; Thomas S Peat; Janet Newman; Lyndall J Briggs; Gauri V Lapalikar; Peter M Campbell; Colin Scott; Robyn J Russell; John G Oakeshott
Journal:  Mol Microbiol       Date:  2010-09-16       Impact factor: 3.501

6.  Mass spectrometric identification and toxicity assessment of degraded products of aflatoxin B1 and B2 by Corymbia citriodora aqueous extracts.

Authors:  Wajiha Iram; Tehmina Anjum; Mazhar Iqbal; Abdul Ghaffar; Mateen Abbas
Journal:  Sci Rep       Date:  2015-10-01       Impact factor: 4.379

7.  Metabolomics of the bio-degradation process of aflatoxin B1 by actinomycetes at an initial pH of 6.0.

Authors:  Manal Eshelli; Linda Harvey; RuAngelie Edrada-Ebel; Brian McNeil
Journal:  Toxins (Basel)       Date:  2015-02-04       Impact factor: 4.546

8.  Aflatoxin B(1) degradation by Stenotrophomonas maltophilia and other microbes selected using coumarin medium.

Authors:  Shu Guan; Cheng Ji; Ting Zhou; Junxia Li; Qiugang Ma; Tiangui Niu
Journal:  Int J Mol Sci       Date:  2008-08-22       Impact factor: 6.208

9.  Aspergillus flavus Growth Inhibition and Aflatoxin B1 Decontamination by Streptomyces Isolates and Their Metabolites.

Authors:  Ixchel Campos-Avelar; Alexandre Colas de la Noue; Noël Durand; Guillaume Cazals; Véronique Martinez; Caroline Strub; Angélique Fontana; Sabine Schorr-Galindo
Journal:  Toxins (Basel)       Date:  2021-05-08       Impact factor: 4.546

Review 10.  Biodegradation of Mycotoxins: Tales from Known and Unexplored Worlds.

Authors:  Ilse Vanhoutte; Kris Audenaert; Leen De Gelder
Journal:  Front Microbiol       Date:  2016-04-25       Impact factor: 5.640
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