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Literature DB >> 6779206

Ordering of mouse immunoglobulin heavy chain genes by molecular cloning.

A Shimizu, N Takahashi, Y Yamawaki-Kataoka, Y Nishida, T Kataoka, T Honjo.

Abstract

We have determined the order of the mouse immunoglobulin gamma 1, gamma 2 b, gamma 2 a and epsilon genes by molecular cloning of overlapping chromosomal segments. The results clearly demonstrate that the order is 5'-gamma 1-(21 kilobases)-gamma 2b-(15 kilobases)-gamma 2a-(15 kilobases)-epsilon-3'. There seem to be no J regions at the 5' side of each constant region gene so far obtained except for the mu gene and these constant region genes seem to have repetitive sequences characteristic of switch (S) regions at their 5' side.

Entities: Gene Species

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Year: 1981 PMID： 6779206 DOI： 10.1038/289149a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

45 in total

Review 1. Mouse map of paralogous genes.

Authors: J H Nadeau; M Kosowsky
Journal: Mamm Genome Date: 1991 Impact factor: 2.957

2. Rearrangement of rat immunoglobulin E heavy-chain and c-myc genes in the B-cell immunocytoma IR162.

Authors: S S Tian; C Faust
Journal: Mol Cell Biol Date: 1987-07 Impact factor: 4.272

3. Differentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cells in vitro.

Authors: T Kinashi; K Inaba; T Tsubata; K Tashiro; R Palacios; T Honjo
Journal: Proc Natl Acad Sci U S A Date: 1988-06 Impact factor: 11.205

4. Independent immunoglobulin class-switch events occurring in a single myeloma cell line.

Authors: L A Eckhardt; B K Birshtein
Journal: Mol Cell Biol Date: 1985-04 Impact factor: 4.272

5. Deletion of a B-cell-specific enhancer affects transfected, but not endogenous, immunoglobulin heavy-chain gene expression.

Authors: D M Zaller; L A Eckhardt
Journal: Proc Natl Acad Sci U S A Date: 1985-08 Impact factor: 11.205

10. Isotype regulation of antibody production: T-cell hybrids can be selectively induced to produce IgG1 and IgG2 subclass-specific suppressive immunoglobulin-binding factors.

Authors: I Löwy; C Brezin; C Neauport-Sautes; J Theze; W H Fridman
Journal: Proc Natl Acad Sci U S A Date: 1983-04 Impact factor: 11.205

Ordering of mouse immunoglobulin heavy chain genes by molecular cloning.

Review 1. Mouse map of paralogous genes.

2. Rearrangement of rat immunoglobulin E heavy-chain and c-myc genes in the B-cell immunocytoma IR162.

3. Differentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cells in vitro.

4. Independent immunoglobulin class-switch events occurring in a single myeloma cell line.

5. Deletion of a B-cell-specific enhancer affects transfected, but not endogenous, immunoglobulin heavy-chain gene expression.

6. Site of unequal sister chromatid exchange contains a potential Z-DNA-forming tract.

7. The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region.

8. Detection of immunoglobulin heavy chain IgG3 polymorphism in wild mice with xenogeneic monoclonal antibodies.

9. Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse.

10. Isotype regulation of antibody production: T-cell hybrids can be selectively induced to produce IgG1 and IgG2 subclass-specific suppressive immunoglobulin-binding factors.