Literature DB >> 6100841

Induction in guinea-pigs of airway hyperreactivity and decreased lung beta-adrenoceptor number by 15-hydroperoxy-arachidonic acid.

G Folkerts, F P Nijkamp, A J van Oosterhout.   

Abstract

Administration to guinea-pigs of 15-hydroperoxy-arachidonic acid (0.2 mg kg-1 i.p.) caused a 20% reduction of lung beta-adrenoceptor number. Furthermore, in vivo, a hyperreactivity of the airways to nebulized histamine was observed. In contrast, administration of 15-hydroxy-arachidonic acid (0.2 mg kg-1 i.p.) did not cause a significant change in either of these parameters.

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Year:  1983        PMID： 6100841      PMCID： PMC2045052          DOI： 10.1111/j.1476-5381.1983.tb10047.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Dexamethasone increases beta-adrenoceptor density in human astrocytoma cells.

Authors:  S J Foster; T K Harden
Journal:  Biochem Pharmacol       Date:  1980-08-01       Impact factor: 5.858

2.  Mediators of immediate hypersensitivity derived from arachidonic acid.

Authors:  E J Goetzl
Journal:  N Engl J Med       Date:  1980-10-02       Impact factor: 91.245

3.  A possible role for lipoxygenase products as regulators of airway smooth muscle reactivity.

Authors:  J J Adcock; L G Garland
Journal:  Br J Pharmacol       Date:  1980-06       Impact factor: 8.739

4.  Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells.

Authors:  P Mallorga; J F Tallman; R C Henneberry; F Hirata; W T Strittmatter; J Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

5.  Phospholipase A2 activity of guinea-pig isolated perfused lungs: stimulation, and inhibition by anti-inflammatory steroids.

Authors:  G J Blackwell; R J Flower; F P Nijkamp; J R Vane
Journal:  Br J Pharmacol       Date:  1978-01       Impact factor: 8.739

6.  Involvement of catecholamines in Haemophilus influenzae induced decrease of beta-adrenoceptor function.

Authors:  A J Schreurs; D H Versteeg; F P Nijkamp
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-09       Impact factor: 3.000

7.  Glucocorticoids increase pulmonary beta-adrenergic receptors in fetal rabbit.

Authors:  J B Cheng; A Goldfien; P L Ballard; J M Roberts
Journal:  Endocrinology       Date:  1980-11       Impact factor: 4.736

8.  Arachidonic acid 15-lipoxygenase products from human eosinophils.

Authors:  J Turk; R L Maas; A R Brash; L J Roberts; J A Oates
Journal:  J Biol Chem       Date:  1982-06-25       Impact factor: 5.157

9.  Bacterial cell wall components decrease the number of guinea-pig lung beta-adrenoceptors.

Authors:  A J Schreurs; J Verhoef; F P Nijkamp
Journal:  Eur J Pharmacol       Date:  1983-01-28       Impact factor: 4.432
  9 in total
  4 in total

Review 1.  Eleventh Gaddum memorial lecture. Lipocortin and the mechanism of action of the glucocorticoids.

Authors:  R J Flower
Journal:  Br J Pharmacol       Date:  1988-08       Impact factor: 8.739

2.  Indomethacin inhibits the increased airway responsiveness to histamine following inhalation of C5a des Arg in rabbits.

Authors:  N Berend; C L Armour; J L Black
Journal:  Agents Actions       Date:  1986-08

3.  Endotoxin-induced hyperreactivity of the guinea-pig isolated trachea coincides with decreased prostaglandin E2 production by the epithelial layer.

Authors:  G Folkerts; F Engels; F P Nijkamp
Journal:  Br J Pharmacol       Date:  1989-02       Impact factor: 8.739

4.  Glucocorticoid-and non-glucocorticoid induction of lipocortins (annexins) 1 and 2 in rat peritoneal leucocytes in vivo.

Authors:  S H Peers; F Smillie; A J Elderfield; R J Flower
Journal:  Br J Pharmacol       Date:  1993-01       Impact factor: 8.739
  4 in total

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