Literature DB >> 6775664

Clinical biochemical aspects of glutaminase toxicity in rabbits and Rhesus monkeys.

P Hambleton, J E Benbough, A Baskerville, P W Harris-Smith.   

Abstract

Treatment with a chemically modified glutaminase was lethal to rabbits and Rhesus monkeys at all but the lowest doses. Changes in the serum levels of triglycerides, glucose, creatinine, urea, cholesterol and protein and in the activities of some serum enzymes were the probable result of the development of lesions in liver, kidney and intestine observed at necropsy. Treatment with unmodified glutaminase induced similar changes in rabbits but not in Rhesus monkeys.

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Year:  1980        PMID： 6775664      PMCID： PMC2041520     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  7 in total

1.  Changes in whole blood and serum components during Francisella tularensis and rabbit pox infections of rabbits.

Authors:  P Hambleton; P W Harris-Smith; N E Bailey; R E Strange
Journal:  Br J Exp Pathol       Date:  1977-12

2.  Reaction-rate assay of serum sorbitol dehydrogenase activity of 37 degrees C.

Authors:  C I Rose; A R Henderson
Journal:  Clin Chem       Date:  1975-10       Impact factor: 8.327

3.  Achromobacter L-glutaminase-L-asparaginase: human pharmacology, toxicology, and activity in acute leukemias.

Authors:  A S Spiers; H E Wade
Journal:  Cancer Treat Rep       Date:  1979-06

4.  Pathological features of glutaminase toxicity.

Authors:  A Baskerville; P Hambleton; J E Benbough
Journal:  Br J Exp Pathol       Date:  1980-04

5.  Automated determination of bacterial asparaginase and glutaminase.

Authors:  H E Wade; B P Phillips
Journal:  Anal Biochem       Date:  1971-11       Impact factor: 3.365

6.  Bacterial glutaminase in treatment of acute leukaemia.

Authors:  A S Spiers; H E Wade
Journal:  Br Med J       Date:  1976-05-29

7.  Changes in whole blood and serum components of grivet monkeys with experimental respiratory Francisella tularensis infection.

Authors:  P Hambleton; A Baskerville; P W Harris-Smith; N E Bailey
Journal:  Br J Exp Pathol       Date:  1978-12
  7 in total
  2 in total

1.  Pathological features of glutaminase toxicity.

Authors:  A Baskerville; P Hambleton; J E Benbough
Journal:  Br J Exp Pathol       Date:  1980-04

2.  The role of glutamine in the immune system and in intestinal function in catabolic states.

Authors:  L M Castell; S J Bevan; P Calder; E A Newsholme
Journal:  Amino Acids       Date:  1994-10       Impact factor: 3.520
  2 in total

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