Literature DB >> 204323

Changes in whole blood and serum components during Francisella tularensis and rabbit pox infections of rabbits.

P Hambleton, P W Harris-Smith, N E Bailey, R E Strange.   

Abstract

Rabbits infected with virulent Francisella tularensis strain Schu S4 or rabbit pox virus (Utrecht strain) showed significant early changes in serum levels of trace metals, neutral fat and alkaline phosphatase activity. With F. tularensis infections a marked early leukopenia and a decrease in serum amino acids were also observed; the effect on amino acid levels was less pronounced in rabbit pox infections. In both diseases these changes preceded the appearance of acute phase globulins in the serum. Vaccination with the live vaccine strain of F. tularensis slightly increased survival times but did not delay the onset of metabolic changes in rabbits subsequently infected with the virulent Schu S4 strain.

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Year:  1977        PMID： 204323      PMCID： PMC2041297     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  29 in total

1.  Detection of a leukocytic endogenous mediator-like mediator of serum amino acid and zinc depression during various infectious illnesses.

Authors:  R W Wannemacher; R S Pekarek; A S Klainer; P J Bartelloni; H L Dupont; R B Hornick; W R Beisel
Journal:  Infect Immun       Date:  1975-04       Impact factor: 3.441

2.  Prophylactic effectiveness of live and killed tularemia vaccines. I. Production of vaccine and evaluation in the white mouse and guinea pig.

Authors:  H T EIGELSBACH; C M DOWNS
Journal:  J Immunol       Date:  1961-10       Impact factor: 5.422

3.  The Cultivation of Bacterium tularense in Embryonated Eggs.

Authors:  C M Downs; L L Coriell; S S Chapman; A Klauber
Journal:  J Bacteriol       Date:  1947-01       Impact factor: 3.490

4.  Relationship of serum beta-glucuronidase and lysozyme to pathogenesis of tularemia in immune and nonimmune rats.

Authors:  P G Canonico; M C Powanda; G L Cockerell; J B Moe
Journal:  Infect Immun       Date:  1975-07       Impact factor: 3.441

5.  Metabolic effects of intracellular infections in man.

Authors:  W R Beisel; W D Sawyer; E D Ryll; D Crozier
Journal:  Ann Intern Med       Date:  1967-10       Impact factor: 25.391

6.  Changes in blood serum constituents and hematologic values in Macaca mulatta with Rocky Mountain spotted fever.

Authors:  L S Sammons; R H Kenyon; G T Burger; C E Pedersen; R O Spertzel
Journal:  Am J Vet Res       Date:  1976-06       Impact factor: 1.156

7.  Pathogenesis and pathology of respiratory tularaemia in the rabbit.

Authors:  A Baskerville; P Hambleton
Journal:  Br J Exp Pathol       Date:  1976-06

8.  Alterations in plasma copper, zinc, amino acids, and seromucoid during Rocky Moutain spotted fever in guinea pigs.

Authors:  M C Powanda; R H Kenyon; J B Moe
Journal:  Proc Soc Exp Biol Med       Date:  1976-04

9.  Induced metabolic sequelae of tularemia in the rat: correlation with tissue damage.

Authors:  M C Powanda; G L Cockerell; J B Moe; F B Abeles; R S Pekarek; P G Canonico
Journal:  Am J Physiol       Date:  1975-08

10.  Pathogenesis of respiratory Klebsiella pneumoniae infection in rats: bacteriological and histological findings and metabolic alterations.

Authors:  R F Berendt; G G Long; F B Abeles; P G Canonico; M R Elwell; M C Powanda
Journal:  Infect Immun       Date:  1977-02       Impact factor: 3.441
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  7 in total

1.  Live attenuated mutants of Francisella tularensis protect rabbits against aerosol challenge with a virulent type A strain.

Authors:  Douglas S Reed; Le'kneitah P Smith; Kelly Stefano Cole; Araceli E Santiago; Barbara J Mann; Eileen M Barry
Journal:  Infect Immun       Date:  2014-03-10       Impact factor: 3.441

2.  Clinical biochemical aspects of glutaminase toxicity in rabbits and Rhesus monkeys.

Authors:  P Hambleton; J E Benbough; A Baskerville; P W Harris-Smith
Journal:  Br J Exp Pathol       Date:  1980-04

3.  Metabolic sequelae of experimental leptospirosis in grivet monkeys.

Authors:  P Hambleton; A Baskerville; R B Marshall; P W Harris-Smith; G D Adams
Journal:  Br J Exp Pathol       Date:  1980-02

4.  Changes in whole blood and serum components of grivet monkeys with experimental respiratory Francisella tularensis infection.

Authors:  P Hambleton; A Baskerville; P W Harris-Smith; N E Bailey
Journal:  Br J Exp Pathol       Date:  1978-12

5.  Pathogenesis and immune response of vaccinated and unvaccinated rhesus monkeys to tick-borne encephalitis virus.

Authors:  P Hambleton; J R Stephenson; A Baskerville; C N Wiblin
Journal:  Infect Immun       Date:  1983-06       Impact factor: 3.441

6.  Pneumonic tularemia in rabbits resembles the human disease as illustrated by radiographic and hematological changes after infection.

Authors:  Douglas S Reed; Le'kneitah Smith; Tammy Dunsmore; Anita Trichel; Luis A Ortiz; Kelly Stefano Cole; Eileen Barry
Journal:  PLoS One       Date:  2011-09-13       Impact factor: 3.240

7.  Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase.

Authors:  Bernard P Arulanandam; Senthilnath Lakshmana Chetty; Jieh-Juen Yu; Sean Leonard; Karl Klose; Janakiram Seshu; Andrew Cap; James J Valdes; James P Chambers
Journal:  J Biol Chem       Date:  2012-08-24       Impact factor: 5.157
  7 in total

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