Literature DB >> 6774280

Effect of osmotic blood-brain barrier disruption on methotrexate pharmacokinetics in the dog.

E A Neuwelt, E P Frenkel, S Rapoport, P Barnett.   

Abstract

Infusion of 25% mannitol into the internal carotid artery of the dog results in a reversible disruption of the blood-brain barrier (BBB). This osmotic BBB disruption enhances the penetratin of systemically administered methotrexate (MTX) into the ipsilateral cerebral hemisphere. Brain methotexate levels were maximized by giving this chemotherapeutic drug by the intracarotid rather than the intravenous route after osmotic BBB disruption. Assays of MTX levels in cerebrospinal fluid were found to be a very unreliable and inconsistent monitor of brain MTX levels after osmotic BBB disruption.

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Year:  1980        PMID： 6774280     DOI： 10.1227/00006123-198007000-00006

Source DB:  PubMed          Journal:  Neurosurgery        ISSN： 0148-396X            Impact factor:   4.654


  16 in total

Review 1.  Permeability imaging in pediatric brain tumors.

Authors:  Sandi Lam; Yimo Lin; Peter C Warnke
Journal:  Transl Pediatr       Date:  2014-07

2.  Increased aqueous flare as a result of a therapeutic dose of mannitol in humans.

Authors:  K Miyake; Y Miyake; K Maekubo
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1992       Impact factor: 3.117

Review 3.  Novel drug delivery strategies in neuro-oncology.

Authors:  Dani S Bidros; Michael A Vogelbaum
Journal:  Neurotherapeutics       Date:  2009-07       Impact factor: 7.620

4.  Chemotherapy administered in conjunction with osmotic blood-brain barrier modification in patients with brain metastases.

Authors:  E A Neuwelt; S A Dahlborg
Journal:  J Neurooncol       Date:  1987       Impact factor: 4.130

5.  Impact of drug size on brain tumor and brain parenchyma delivery after a blood-brain barrier disruption.

Authors:  Marie Blanchette; Luc Tremblay; Martin Lepage; David Fortin
Journal:  J Cereb Blood Flow Metab       Date:  2014-02-12       Impact factor: 6.200

6.  Effect of mannitol infusions into the internal carotid artery on entry of two antibiotics into the cerebrospinal fluid and brains of normal rabbits.

Authors:  B A Perkins; L J Strausbaugh
Journal:  Antimicrob Agents Chemother       Date:  1983-09       Impact factor: 5.191

7.  Intra-arterial chemotherapy with osmotic blood-brain barrier disruption for aggressive oligodendroglial tumors: results of a phase I study.

Authors:  Daniel J Guillaume; Nancy D Doolittle; Seymur Gahramanov; Nancy A Hedrick; Johnny B Delashaw; Edward A Neuwelt
Journal:  Neurosurgery       Date:  2010-01       Impact factor: 4.654

8.  Primary central nervous system lymphoma.

Authors:  Manmeet S Ahluwalia; David M Peereboom
Journal:  Curr Treat Options Neurol       Date:  2010-07       Impact factor: 3.598

Review 9.  A critique of the role of the blood-brain barrier in the chemotherapy of human brain tumors.

Authors:  D J Stewart
Journal:  J Neurooncol       Date:  1994       Impact factor: 4.130

10.  Effect of osmotic blood-brain barrier disruption on gentamicin penetration into the cerebrospinal fluid and brains of normal rabbits.

Authors:  L J Strausbaugh; G S Brinker
Journal:  Antimicrob Agents Chemother       Date:  1983-08       Impact factor: 5.191
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