Literature DB >> 6772786

Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.

G Tsukamoto, K Yoshino, T Kohno, H Ohtaka, H Kagaya, K Ito.   

Abstract

A series of 2-(2-pyridinyl)benzimidazoles was synthesized and evaluated for antiinflammatory activity by the carrageenan-induced rat paw edema assay. Among several active derivatives, 2-(5-ethylpyridin-2-yl)benzimidazole (6) was selected for further study. A comparison of compound 6 with phenylbutazone and tiaramide revealed that 6 possesses stronger activity in acute inflammatory models possibly with slightly less gastrointestinal irritation than both phenylbutazone and tiaramide.

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Year:  1980        PMID： 6772786     DOI： 10.1021/jm00181a007

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  5 in total

1.  Design and synthesis of CK2 inhibitors.

Authors:  Małgorzata Makowska; Edyta Łukowska-Chojnacka; Patrycja Wińska; Agnieszka Kuś; Aleksandra Bilińska-Chomik; Maria Bretner
Journal:  Mol Cell Biochem       Date:  2011-07-13       Impact factor: 3.396

2.  In vivo metabolism of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole.

Authors:  O Caputo; G Grosa; M Ceruti; F Viola; F Rocco
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1989 Oct-Dec       Impact factor: 2.441

3.  In vitro metabolism of 2-(5-ethylpyridin-2-yl)benzimidazole.

Authors:  O Caputo; G Grosa; G Balliano; F Rocco; G Biglino
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1988 Jan-Mar       Impact factor: 2.441

4.  1-benzyl-2-phenylbenzimidazole (BPB), a benzimidazole derivative, induces cell apoptosis in human chondrosarcoma through intrinsic and extrinsic pathways.

Authors:  Ju-Fang Liu; Yuan-Li Huang; Wei-Hung Yang; Chih-Shiang Chang; Chih-Hsin Tang
Journal:  Int J Mol Sci       Date:  2012-12-04       Impact factor: 5.923

5.  Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer.

Authors:  Fiona Scott; Angela M Fala; Lewis E Pennicott; Tristan D Reuillon; Katlin B Massirer; Jonathan M Elkins; Simon E Ward
Journal:  Bioorg Med Chem Lett       Date:  2020-02-17       Impact factor: 2.823
  5 in total

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