Literature DB >> 3260865

In vitro metabolism of 2-(5-ethylpyridin-2-yl)benzimidazole.

O Caputo1, G Grosa, G Balliano, F Rocco, G Biglino.   

Abstract

The in vitro metabolic transformation of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied with phenobarbital and 3-methylcholanthrene induced rat liver microsomal fractions containing an NADPH-generating system. The major metabolite was a benzylic oxidation product and a secondary metabolite was also recovered. The metabolites were isolated by TLC and HPLC techniques and identified by comparison with known pure compounds.

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Year:  1988        PMID： 3260865     DOI： 10.1007/BF03189928

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  7 in total

1.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

2.  Alcohol mixed function. Oxidase activity of mammalian liver microsomes.

Authors:  W H Orme-Johnson; D M Ziegler
Journal:  Biochem Biophys Res Commun       Date:  1965-10-08       Impact factor: 3.575

3.  Effect of phenobarbital treatment of the sterochemistry of the in vitro metabolism of ethylbenzene.

Authors:  G A Maylin; M J Cooper; M W Anders
Journal:  J Med Chem       Date:  1973-06       Impact factor: 7.446

Review 4.  Function and structure of liver alcohol dehydrogenase.

Authors:  H Theorell
Journal:  Harvey Lect       Date:  1967

5.  The studies of the mechanism of antiinflammatory action of 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043).

Authors:  K Ito; H Kagaya; I Satoh; G Tsukamoto; T Nose
Journal:  Arzneimittelforschung       Date:  1982

6.  Pharmacological studies of a new non-steroidal antiinflammatory drug: 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043).

Authors:  K Ito; H Kagaya; T Fukuda; K Yoshino; T Nose
Journal:  Arzneimittelforschung       Date:  1982

7.  Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.

Authors:  G Tsukamoto; K Yoshino; T Kohno; H Ohtaka; H Kagaya; K Ito
Journal:  J Med Chem       Date:  1980-07       Impact factor: 7.446
  7 in total
  2 in total

1.  In vivo metabolism of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole.

Authors:  O Caputo; G Grosa; M Ceruti; F Viola; F Rocco
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1989 Oct-Dec       Impact factor: 2.441

2.  The metabolic fate of the anti-parkinsonian drug budipine in rats.

Authors:  O Caputo; G Grosa; M Ceruti; F Rocco; G Biglino
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1991 Apr-Jun       Impact factor: 2.441
  2 in total

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