Explanation of cerebral white--gray contrast in computed tomography.

The difference in Hounsfield number between white and gray brain tissue is calculated from published chemical compositions and density values. The result of 5.5 Hounsfield units at typical CT energies is in excellent agreement with experiments. The difference arises because gray matter contains 8% more oxygen and 8% less carbon, due to its higher water and lower lipid content, and this increases the photoelectric absorption. Efforts to obtain greater contrast by lowering the X-ray energy will be offset by the noise increase at low energies.