S F Brandão1, T P R Campos1. 1. Departamento de Engenharia Nuclear, Universidade Federal de Minas Gerais, Escola de Engenharia, Belo Horizonte, Minas Gerais, Brazil.
Abstract
OBJECTIVE: This article proposes a combination of californium-252 ((252)Cf) brachytherapy, boron neutron capture therapy (BNCT) and an intracavitary moderator balloon catheter applied to brain tumour and infiltrations. METHODS: Dosimetric evaluations were performed on three protocol set-ups: (252)Cf brachytherapy combined with BNCT (Cf-BNCT); Cf-BNCT with a balloon catheter filled with light water (LWB) and the same set-up with heavy water (HWB). RESULTS: Cf-BNCT-HWB has presented dosimetric advantages to Cf-BNCT-LWB and Cf-BNCT in infiltrations at 2.0-5.0 cm from the balloon surface. However, Cf-BNCT-LWB has shown superior dosimetry up to 2.0 cm from the balloon surface. CONCLUSION: Cf-BNCT-HWB and Cf-BNCT-LWB protocols provide a selective dose distribution for brain tumour and infiltrations, mainly further from the (252)Cf source, sparing the normal brain tissue. ADVANCES IN KNOWLEDGE: Malignant brain tumours grow rapidly and often spread to adjacent brain tissues, leading to death. Improvements in brain radiation protocols have been continuously achieved; however, brain tumour recurrence is observed in most cases. Cf-BNCT-LWB and Cf-BNCT-HWB represent new modalities for selectively combating brain tumour infiltrations and metastasis.
OBJECTIVE: This article proposes a combination of californium-252 ((252)Cf) brachytherapy, boron neutron capture therapy (BNCT) and an intracavitary moderator balloon catheter applied to brain tumour and infiltrations. METHODS: Dosimetric evaluations were performed on three protocol set-ups: (252)Cf brachytherapy combined with BNCT (Cf-BNCT); Cf-BNCT with a balloon catheter filled with light water (LWB) and the same set-up with heavy water (HWB). RESULTS: Cf-BNCT-HWB has presented dosimetric advantages to Cf-BNCT-LWB and Cf-BNCT in infiltrations at 2.0-5.0 cm from the balloon surface. However, Cf-BNCT-LWB has shown superior dosimetry up to 2.0 cm from the balloon surface. CONCLUSION: Cf-BNCT-HWB and Cf-BNCT-LWB protocols provide a selective dose distribution for brain tumour and infiltrations, mainly further from the (252)Cf source, sparing the normal brain tissue. ADVANCES IN KNOWLEDGE: Malignant brain tumours grow rapidly and often spread to adjacent brain tissues, leading to death. Improvements in brain radiation protocols have been continuously achieved; however, brain tumour recurrence is observed in most cases. Cf-BNCT-LWB and Cf-BNCT-HWB represent new modalities for selectively combating brain tumour infiltrations and metastasis.
Authors: Andrea Wittig; Finn Stecher-Rasmussen; Ralf A Hilger; Jürgen Rassow; Pierluigi Mauri; Wolfgang Sauerwein Journal: Appl Radiat Isot Date: 2011-03-21 Impact factor: 1.513
Authors: K J Riley; P J Binns; O K Harling; J R Albritton; W S Kiger; A Rezaei; K Sköld; T Seppälä; S Savolainen; I Auterinen; M Marek; L Viererbl; V A Nievaart; R L Moss Journal: Med Phys Date: 2008-12 Impact factor: 4.071
Authors: Matthew R Palmer; J Timothy Goorley; W S Kiger; Paul M Busse; Kent J Riley; Otto K Harling; Robert G Zamenhof Journal: Int J Radiat Oncol Biol Phys Date: 2002-08-01 Impact factor: 7.038
Authors: G S Cruickshank; D Ngoga; A Detta; S Green; N D James; C Wojnecki; J Doran; J Hardie; M Chester; N Graham; Z Ghani; G Halbert; M Elliot; S Ford; R Braithwaite; T M T Sheehan; J Vickerman; N Lockyer; H Steinfeldt; G Croswell; A Chopra; R Sugar; A Boddy Journal: Appl Radiat Isot Date: 2009-03-26 Impact factor: 1.513
Authors: A Gabriella Wernicke; David L Sherr; Theodore H Schwartz; Susan C Pannullo; Philip E Stieg; John A Boockvar; Jennifer A Moliterno; Jana Ivanidze; Samuel Trichter; Albert M Sabbas; Bhupesh Parashar; Dattatreyudu Nori Journal: Brachytherapy Date: 2009-10-21 Impact factor: 2.362
Authors: Rolf F Barth; M Graca H Vicente; Otto K Harling; W S Kiger; Kent J Riley; Peter J Binns; Franz M Wagner; Minoru Suzuki; Teruhito Aihara; Itsuro Kato; Shinji Kawabata Journal: Radiat Oncol Date: 2012-08-29 Impact factor: 3.481