Literature DB >> 677125

A note on the essential parameters of the two-allele autosomal locus model.

P M Fishman, T Reich, B Suarez, J W James.   

Abstract

A resolution of the parameter problem for the two-allele autosomal locus (TAAL) model has been presented. It was shown that three are four essential parameters which describe the model, by examination of the joint probability for sibs with specified parental phenotypes. This equation together with previously derived prevalence relationships uniquely specifices all parameters of the model except for the singular case VA = 0.

Mesh：

Year:  1978        PMID： 677125      PMCID： PMC1685580     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  14 in total

1.  General models for segregation analysis.

Authors:  R C Elston; K C Yelverton
Journal:  Am J Hum Genet       Date:  1975-01       Impact factor: 11.025

2.  Limits of the general two-allele single locus model with incomplete penetrance.

Authors:  B K Suarez; T Reich; J Trost
Journal:  Ann Hum Genet       Date:  1976-11       Impact factor: 1.670

3.  Diabetes mellitus: discrimination between single locus and multifactorial models of inheritance.

Authors:  M J Goodman; C S Chung
Journal:  Clin Genet       Date:  1975-07       Impact factor: 4.438

4.  Analysis of family resemblance. 3. Complex segregation of quantitative traits.

Authors:  N E Morton; C J MacLean
Journal:  Am J Hum Genet       Date:  1974-07       Impact factor: 11.025

5.  The use of multiple thresholds in determining the mode of transmission of semi-continuous traits.

Authors:  T Reich; J W James; C A Morris
Journal:  Ann Hum Genet       Date:  1972-11       Impact factor: 1.670

6.  Complex segregation analysis.

Authors:  N E Morton; S Yee; R Lew
Journal:  Am J Hum Genet       Date:  1971-11       Impact factor: 11.025

7.  A general model for the genetic analysis of pedigree data.

Authors:  R C Elston; J Stewart
Journal:  Hum Hered       Date:  1971       Impact factor: 0.444

8.  Discriminating between different modes of inheritance in genetic disease.

Authors:  C Smith
Journal:  Clin Genet       Date:  1971       Impact factor: 4.438

9.  Estimating the parameters of the incompletely penetrant single locus model using multiple populations.

Authors:  B K Suarez; P M Fishman; T Reich
Journal:  Hum Hered       Date:  1977       Impact factor: 0.444

10.  Analysis of family resemblance. IV. Operational characteristics of segregation analysis.

Authors:  C J MacLean; N E Morton; R Lew
Journal:  Am J Hum Genet       Date:  1975-05       Impact factor: 11.025
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  3 in total

1.  Recurrence risks in schizophrenia: are they model dependent?

Authors:  L A Morton; K K Kidd; S W Matthysse; R L Richards
Journal:  Behav Genet       Date:  1979-09       Impact factor: 2.805

2.  BF types and the mode of inheritance of insulin-dependent diabetes mellitus (IDDM).

Authors:  D Raum; Z Awdeh; C A Alper
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

3.  Refutation of the general single-locus model for the etiology of schizophrenia.

Authors:  D H O'Rourke; I I Gottesman; B K Suarez; J Rice; T Reich
Journal:  Am J Hum Genet       Date:  1982-07       Impact factor: 11.025
  3 in total

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