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Literature DB >> 6769740

Serum secretory component level in myeloma patients with disorders of the secretory surface.

K Kunishi, T Arima, T Yasuhara, J Narumoto, K Suwaki, S Kita, H Nagashima.

Abstract

Secretory component (SC) in myeloma serum was measured by a double antibody radioimmunoassay. It was elevated in patients with IgA myeloma and the highest level was observed in a patient with macroglobulinemia. The presence of disorders of secretory surface in myeloma patients slightly but not significantly elevated the serum SC concentration. A significant correlation between serum SC and IgG is demonstrated, but not between serum SC and IgA. Over the whole patient groups, serum SC is significantly related to serum IgM but not when patients with macroglobulinemia are excluded from the calculation. Serum SC is present as SC-IgM in macroglobulinemia and SC-IgM and SC-IgA in IgA myeloma.

Entities: Disease Species

Mesh：

Substances：

Year: 1980 PMID： 6769740 DOI： 10.1007/bf02774929

Source DB: PubMed Journal: Gastroenterol Jpn ISSN： 0435-1339

10 in total

1. Increased risistance of immunoglobulin A dimers to proteolytic degradation after binding of secretory component.

Authors: E Lindh
Journal: J Immunol Date: 1975-01 Impact factor: 5.422

2. A study of the association of human secretory component with IgA and IgM proteins.

Authors: J Weicker; B J Underdown
Journal: J Immunol Date: 1975-04 Impact factor: 5.422

3. Binding of secretory piece to polymeric IgA and IgM paraproteins in vitro.

Authors: J Rádl; F Klein; P van den Berg; A M de Bruyn; W Hijmans
Journal: Immunology Date: 1971-05 Impact factor: 7.397

4. Secretory IgA in the serum.

Authors: R A Thompson; P Asquith; W T Cooke
Journal: Lancet Date: 1969-09-06 Impact factor: 79.321

5. The decrease of human colostral immunoglobulin A resistance to papain action after gradual release of the secretory component.

Authors: V Gheţie; G Mota
Journal: Immunochemistry Date: 1973-12

2 in total

1. Studies on secretory component in digestive disease. III. Levels of serum secretory component in digestive disease.

Authors: K Kunishi
Journal: Gastroenterol Jpn Date: 1980

2. Studies on secretory component in digestive disease. IV. Levels of serum secretory component in liver disease.

Authors: K Kunishi; T Arima; T Yasuhara; J Narumoto; K Suwaki; H Nagashima
Journal: Gastroenterol Jpn Date: 1980

2 in total

Serum secretory component level in myeloma patients with disorders of the secretory surface.

1. Increased risistance of immunoglobulin A dimers to proteolytic degradation after binding of secretory component.

2. A study of the association of human secretory component with IgA and IgM proteins.

3. Binding of secretory piece to polymeric IgA and IgM paraproteins in vitro.

4. Secretory IgA in the serum.

5. The decrease of human colostral immunoglobulin A resistance to papain action after gradual release of the secretory component.

6. Immunochemical quantitation of antigens by single radial immunodiffusion.

7. Complex formation between secretory component and human immunoglobulins related to their content of J chain.

8. A radioimmunoassay for quantitation of secretory component.

9. Secretory IgA in human serum.

10. Quantitation of exocrine IgA in human serum in health and disease.

1. Studies on secretory component in digestive disease. III. Levels of serum secretory component in digestive disease.

2. Studies on secretory component in digestive disease. IV. Levels of serum secretory component in liver disease.