Literature DB >> 6769055

Induction of rat hepatic UDP-glucuronosyltransferases by dietary ethoxyquin.

K W Bock, R Kahl, W Lilienblum.   

Abstract

Dietary administration of 0.5% ethoxyquin markedly enhanced rat hepatic UDP-glucuronosyltransferase activities. Both 3-methylcholanthrene- and phenobarbital-inducible glucuronidation reactions were stimulated by the antioxidant. In contrast, phenobarbital-inducible bilirubin glucuronidation was not affected by ethoxyquin.

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Year:  1980        PMID： 6769055     DOI： 10.1007/bf00499919

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  11 in total

1.  Demonstration of functional heterogeneity of hepatic uridine diphosphate glucuronosyltransferase activities after administration of 3-methylcholanthrene and phenobarbital to rats.

Authors:  G J Wishart
Journal:  Biochem J       Date:  1978-08-15       Impact factor: 3.857

2.  Ethoxyquin as an inducer and inhibitor of phenobarbital-type cytochrome P-450 in rat liver microsomes.

Authors:  R Kahl; K J Netter
Journal:  Toxicol Appl Pharmacol       Date:  1977-06       Impact factor: 4.219

3.  Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants.

Authors:  A M Benson; R P Batzinger; S Y Ou; E Bueding; Y N Cha; P Talalay
Journal:  Cancer Res       Date:  1978-12       Impact factor: 12.701

4.  Effects of 2(3)-tert-butyl-4-hydroxyanisole administration on the activities of several hepatic microsomal and cytoplasmic enzymes in mice.

Authors:  Y N Cha; E Bueding
Journal:  Biochem Pharmacol       Date:  1979-06-15       Impact factor: 5.858

5.  Induction of rat hepatic epoxide hydratase by dietary antioxidants.

Authors:  R Kahl; U Wulff
Journal:  Toxicol Appl Pharmacol       Date:  1979-02       Impact factor: 4.219

6.  Reversibility of hepatic changes caused by ethoxyquin.

Authors:  D V Parke; A Rahim; R Walker
Journal:  Biochem Pharmacol       Date:  1974-07-01       Impact factor: 5.858

7.  Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin.

Authors:  L W Wattenberg
Journal:  J Natl Cancer Inst       Date:  1972-05       Impact factor: 13.506

Review 8.  Commentary: Control of UDP-glucuronyltransferase activity.

Authors:  G J Dutton
Journal:  Biochem Pharmacol       Date:  1975-10-15       Impact factor: 5.858

9.  Ethoxyquin feeding to rats increases liver microsome-catalyzed formation of benzo(a)pyrene diol epoxide--DNA adduct.

Authors:  R Kahl; B Deckers-Schmelzle; E Klaus
Journal:  Biochem Biophys Res Commun       Date:  1978-12-14       Impact factor: 3.575

10.  Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital.

Authors:  K W Bock; D Josting; W Lilienblum; H Pfeil
Journal:  Eur J Biochem       Date:  1979-07
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  1 in total

1.  An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases.

Authors:  E M Ellis; D J Judah; G E Neal; J D Hayes
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205
  1 in total

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