Literature DB >> 6768802

Definitive mapping of the immune response gene(s) for (T,G)-A--L to the I-A subregion.

M Markman, H B Dickler.   

Abstract

Mice of strains B10, B10.A, B10.A(4R), B10.A(5R), and the new recombinant inbred strain B10.MBR (H-2 genotype Kb, Ik, Sk. Dq) were immunized with (T,G)-A--L and the primary (total and IgM component), and secondary antibody responses were measured by using radioimmunoassays. B10 and B10.A(5R) were high responders, whereas B10.A, B10.A(4R), and B10.MBR were low responders to (T,G)-A--L. Based on the genotypes of the strains utilized, the immune response gene(s) for (T,G)-A--L is located in the I-A subregion of the H-2 complex. The data are consistent with the concept that Ia antigens are Ir gene products.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6768802

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  5 in total

1.  Sequence analysis and structure-function correlations of murine q, k, u, s, and f haplotype I-A beta cDNA clones.

Authors:  P Estess; A B Begovich; M Koo; P P Jones; H O McDevitt
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

2.  Selective loss of antigen-specific Ir gene function in IA mutant B6.C-H-2bm12 is an antigen presenting cell defect.

Authors:  C C Lin; A S Rosenthal; H C Passmore; T H Hansen
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

3.  In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A.

Authors:  J T Rosenbaum; N E Adelman; H O McDevitt
Journal:  J Exp Med       Date:  1981-11-01       Impact factor: 14.307

4.  Antiidiotype stimulation of antigen-specific antigen-independent antibody responses in vitro. I. Evidence for stimulation of helper T lymphocyte function.

Authors:  H Z Weissberger; R R Shenk; H B Dickler
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307

5.  Antigen-reactive T cell clones. II. Unique homozygous and (high responder x low responder)F1 hybrid antigen-presenting determinants detected using poly(Tyr, Glu)-poly D, L-Ala--poly Lys-reactive T cell clones.

Authors:  M Kimoto; C G Fathman
Journal:  J Exp Med       Date:  1981-02-01       Impact factor: 14.307
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.