Literature DB >> 6766532

An immunoglobulin heavy-chain gene is formed by at least two recombinational events.

M M Davis, K Calame, P W Early, D L Livant, R Joho, I L Weissman, L Hood.   

Abstract

The events of B-cell differentiation can be reconstructed in part through an analysis of the organisation of heavy-chain gene segments in differentiated B cells. A mouse immunoglobulin alpha heavy-chain gene is composed of at least three noncontiguous germ-line DNA segments--a VH gene segment, a JH gene segment associated with the Cmu gene segment, and the C alpha gene segment. These gene segments are joined together by two distinct types of DNA rearrangements--a V-J joining and a CH switch.

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Year:  1980        PMID： 6766532     DOI： 10.1038/283733a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  96 in total

1.  Copy choice mechanism of immunoglobulin heavy-chain switch recombination.

Authors:  W Dunnick; J Stavnezer
Journal:  Mol Cell Biol       Date:  1990-01       Impact factor: 4.272

2.  Unusual molecular characteristics of a repeat sequence island within a Giemsa-positive band on the mouse X chromosome.

Authors:  J Nasir; E M Fisher; N Brockdorff; C M Disteche; M F Lyon; S D Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

Review 3.  The early history of B cells.

Authors:  Max D Cooper
Journal:  Nat Rev Immunol       Date:  2015-02-06       Impact factor: 53.106

4.  DNA sequence of a class I pseudogene from the Tla region of the murine MHC: recombination at a B2 alu repetitive sequence.

Authors:  D A Fisher; M Pecht; L Hood
Journal:  J Mol Evol       Date:  1989-04       Impact factor: 2.395

5.  Mutational analysis of the immunoglobulin heavy chain promoter region.

Authors:  D W Ballard; A Bothwell
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

6.  Complete nucleotide sequences of three VH genes in Caiman, a phylogenetically ancient reptile: evolutionary diversification in coding segments and variation in the structure and organization of recombination elements.

Authors:  G W Litman; K Murphy; L Berger; R Litman; K Hinds; B W Erickson
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

7.  Unique sequences are interspersed among tandemly repeated elements in the murine gamma 1 switch segment.

Authors:  M Mowatt; C Dery; W Dunnick
Journal:  Nucleic Acids Res       Date:  1985-01-11       Impact factor: 16.971

8.  Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type beta-induced isotype switching.

Authors:  D A Lebman; D Y Nomura; R L Coffman; F D Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

9.  Expression of an immunoglobulin heavy chain gene transfected into lymphocytes.

Authors:  R J Deans; K A Denis; A Taylor; R Wall
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

10.  The temporal order of replication of murine immunoglobulin heavy chain constant region sequences corresponds to their linear order in the genome.

Authors:  J D Braunstein; D Schulze; T DelGiudice; A Furst; C L Schildkraut
Journal:  Nucleic Acids Res       Date:  1982-11-11       Impact factor: 16.971
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