Literature DB >> 6762209

A cysteine proteinase secreted from human breast tumours is immunologically related to cathepsin B.

A D Recklies, A R Poole, J S Mort.   

Abstract

The stable cathepsin B-like cysteine (thiol) proteinase secreted from human breast tumours in culture was shown to be destabilized by mercurial compounds. After such treatment the enzyme cross-reacts in a radioimmunoassay with a monospecific antiserum to human liver cathepsin B. It is suggested that the secreted enzyme may be a precursor form of lysosomal cathepsin B.

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Year:  1982        PMID： 6762209      PMCID： PMC1153912          DOI： 10.1042/bj2070633

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  Evidence that latent collagenases are enzyme-inhibitor complexes.

Authors:  A Sellers; E Cartwright; G Murphy; J J Reynolds
Journal:  Biochem J       Date:  1977-05-01       Impact factor: 3.857

2.  Neutral metallo-proteinases of rabbit bone. Separation in latent forms of distinct enzymes that when activated degrade collagen, gelatin and proteoglycans.

Authors:  A Sellers; J J Reynolds; M C Meikle
Journal:  Biochem J       Date:  1978-05-01       Impact factor: 3.857

3.  An improved color reagent for use in Barrett's assay of Cathepsin B.

Authors:  A J Barrett
Journal:  Anal Biochem       Date:  1976-11       Impact factor: 3.365

Review 4.  Role of granulocyte collagenase in collagen degradation.

Authors:  G S Lazarus; J R Daniels; J Lian; M C Burleigh
Journal:  Am J Pathol       Date:  1972-09       Impact factor: 4.307

5.  Chromatographic evidence for the existence of multiple forms of cathepsin B1.

Authors:  S G Franklin; R M Metrione
Journal:  Biochem J       Date:  1972-03       Impact factor: 3.857

6.  A radioimmunoassay for total human cathepsin B.

Authors:  A D Recklies; J S Mort
Journal:  Clin Chim Acta       Date:  1982-08-04       Impact factor: 3.786

7.  Immunofluorescent localization of cathepsins B and D in human fibroblasts.

Authors:  J S Mort; A R Poole; R S Decker
Journal:  J Histochem Cytochem       Date:  1981-05       Impact factor: 2.479

8.  Characterization of a thiol proteinase secreted by malignant human breast tumours.

Authors:  J S Mort; A D Recklies; A R Poole
Journal:  Biochim Biophys Acta       Date:  1980-07-10

9.  Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas.

Authors:  A R Poole; K J Tiltman; A D Recklies; T A Stoker
Journal:  Nature       Date:  1978-06-15       Impact factor: 49.962

10.  Secretion of proteinases from malignant and nonmalignant human breast tissue.

Authors:  A D Recklies; K J Tiltman; T A Stoker; A R Poole
Journal:  Cancer Res       Date:  1980-03       Impact factor: 12.701
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  11 in total

1.  Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme.

Authors:  L Mach; K Stüwe; A Hagen; C Ballaun; J Glössl
Journal:  Biochem J       Date:  1992-03-01       Impact factor: 3.857

Review 2.  Drug development against metastasis-related genes and their pathways: a rationale for cancer therapy.

Authors:  Megumi Iiizumi; Wen Liu; Sudha K Pai; Eiji Furuta; Kounosuke Watabe
Journal:  Biochim Biophys Acta       Date:  2008-07-22

3.  Interrelationship of active and latent secreted human cathepsin B precursors.

Authors:  J S Mort; A D Recklies
Journal:  Biochem J       Date:  1986-01-01       Impact factor: 3.857

4.  A catalytically active high-Mr form of human cathepsin B from sputum.

Authors:  D J Buttle; B C Bonner; D Burnett; A J Barrett
Journal:  Biochem J       Date:  1988-09-15       Impact factor: 3.857

Review 5.  Cathepsin B and its endogenous inhibitors: the role in tumor malignancy.

Authors:  B F Sloane; K Moin; E Krepela; J Rozhin
Journal:  Cancer Metastasis Rev       Date:  1990-12       Impact factor: 9.264

6.  A novel leupeptin-sensitive serine endopeptidase present in normal and malignant rat mammary tissues.

Authors:  I Eto; M D Bandy
Journal:  Mol Cell Biochem       Date:  1990-04-18       Impact factor: 3.396

Review 7.  Cysteine proteinases and metastasis.

Authors:  B F Sloane; K V Honn
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264

Review 8.  Collagenolytic mechanisms in tumor cell invasion.

Authors:  D E Woolley
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264

9.  Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival.

Authors:  E Campo; J Muñoz; R Miquel; A Palacín; A Cardesa; B F Sloane; M R Emmert-Buck
Journal:  Am J Pathol       Date:  1994-08       Impact factor: 4.307

10.  Separation, purification and N-terminal sequence analysis of a novel leupeptin-sensitive serine endopeptidase present in chemically induced rat mammary tumour.

Authors:  I Eto; C J Grubbs
Journal:  Biochem J       Date:  1992-04-01       Impact factor: 3.857
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