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Literature DB >> 6760807

Homogeneous enzyme immunoassay for netilmicin.

Abstract

A newly developed homogeneous enzyme immunoassay for the determination of netilmicin in serum was evaluated and compared with a radioenzymatic assay. A total of 102 serum samples from patients treated with netilmicin were measured by both methods. This comparison showed an excellent correlation (r = 0.993). The enzyme immunoassay has proved to be precise, accurate, and specific. Because of its rapidity and the ease of performance, this method is a useful alternative to current assays for monitoring serum netilmicin concentrations.

Entities: Chemical Species

Mesh：

Substances：
Gentamicins
Netilmicin

Year: 1982 PMID： 6760807 PMCID： PMC185699 DOI： 10.1128/AAC.22.6.954

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

1. In vitro studies on netilmicin, a new aminoglycoside antibiotic.

Authors: D Stewart; G P Bodey; B LeBlanc
Journal: Antimicrob Agents Chemother Date: 1977-06 Impact factor: 5.191

Review 2. Determination of aminoglycoside antibiotics in biological fluids: a review.

Authors: S K Maitra; T T Yoshikawa; L B Guze; M C Schotz
Journal: Clin Chem Date: 1979-08 Impact factor: 8.327

3. The acetyltransferase enzyme method for the assay of serum gentamicon concentrations and a comparison with other methods.

Authors: J M Broughall; D S Reeves
Journal: J Clin Pathol Date: 1975-02 Impact factor: 3.411

Homogeneous enzyme immunoassay for netilmicin.

1. In vitro studies on netilmicin, a new aminoglycoside antibiotic.

Review 2. Determination of aminoglycoside antibiotics in biological fluids: a review.

3. The acetyltransferase enzyme method for the assay of serum gentamicon concentrations and a comparison with other methods.

4. Rapid, reproducible enzyme immunoassay for tobramycin.

5. Improving the sensitivity of gentamicin enzyme immunoassay.

6. Evaluation of an enzyme immunoassay for serum gentamicin.

7. Plasma concentration monitoring of aminoglycosides.

8. Comparative nephrotoxicities of netilmicin and gentamicin in rats.

9. Comparative ototoxic liability of netilmicin and gentamicin.

10. Multicompartment pharmacokinetics of netilmicin.

Review 1. Netilmicin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

2. Effect of cardiopulmonary bypass on vancomycin and netilmicin disposition.

Review 3. Serum level monitoring of antibacterial drugs. A review.