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Literature DB >> 6760112

Ionic determinants of bioelectrical spiking activity in the pancreatic B-cell.

Abstract

A rise in extracellular glucose concentration from 8.3 to 16.7 mM stimulates both Ca2+ inflow and K+ exit in perfused rat pancreatic islets. These ionic changes are associated with an increase in bioelectrical spiking activity. From a quantitative analysis of 45Ca and 86Rb outflow from prelabelled islets, it is proposed that each electrical spike coincides, approximately, with the entry of 0.8 fmol of Ca2+ and exit of 3.6 fmol of K+ per mm2 of cell surface.

Entities: Chemical Species

Mesh：

Substances：
Glucose
Potassium
Calcium

Year: 1982 PMID： 6760112 DOI： 10.1007/bf00584810

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

20 in total

1. Glucose-induced decrease in Rb+ permeability in pancreatic beta cells.

Authors: J Sehlin; I B Taljedal
Journal: Nature Date: 1975-02-20 Impact factor: 49.962

2. Glucose-induced changes of the membrane potential of pancreatic B-cells: their significance for the regulation of insulin release.

Authors: H P Meissner; M Preissler
Journal: Adv Exp Med Biol Date: 1979 Impact factor: 2.622

3. Effect of glucose on K+ handling by pancreatic islets.

Authors: A C Boschero; S Kawazu; G Duncan; W J Malaisse
Journal: FEBS Lett Date: 1977-11-01 Impact factor: 4.124

4. The stimulus-secretion coupling of glucose-induced insulin release. XXVIII. Effect of glucose on Na+ fluxes in isolated islets.

Authors: S Kawazu; A C Boschero; C Delcroix; W J Malaisse
Journal: Pflugers Arch Date: 1978-07-18 Impact factor: 3.657

5. Calcium antagonists and islet function: VII. Effect of calcium deprivation.

Authors: W J Malaisse; J C Hutton; A Sener; J Levy; A Herchuelz; G Devis; G Somers
Journal: J Membr Biol Date: 1978-01-18 Impact factor: 1.843

6. Regulation of 86Rb+ outflow from pancreatic islets. I. Reciprocal changes in the response to glucose, tetraethylammonium and quinine.

Authors: A Carpinelli; W J Malaisse
Journal: Mol Cell Endocrinol Date: 1980-02 Impact factor: 4.102

7. Stimulus-secretion coupling of glucose-induced insulin release. XXIX. Regulation of 86Rb+ efflux from perfused islets.

Authors: A C Boschero; W J Malaisse
Journal: Am J Physiol Date: 1979-02

1. Inosine partially mimics the effects of glucose on ionic fluxes, electrical activity, and insulin release in mouse pancreatic B-cells.

Authors: M Bozem; M G Garrino; J C Henquin
Journal: Pflugers Arch Date: 1987-11 Impact factor: 3.657

Ionic determinants of bioelectrical spiking activity in the pancreatic B-cell.

1. Glucose-induced decrease in Rb+ permeability in pancreatic beta cells.

2. Glucose-induced changes of the membrane potential of pancreatic B-cells: their significance for the regulation of insulin release.

3. Effect of glucose on K+ handling by pancreatic islets.

4. The stimulus-secretion coupling of glucose-induced insulin release. XXVIII. Effect of glucose on Na+ fluxes in isolated islets.

5. Calcium antagonists and islet function: VII. Effect of calcium deprivation.

6. Regulation of 86Rb+ outflow from pancreatic islets. I. Reciprocal changes in the response to glucose, tetraethylammonium and quinine.

7. Stimulus-secretion coupling of glucose-induced insulin release. XXIX. Regulation of 86Rb+ efflux from perfused islets.

8. Regulation of calcium fluxes in rat pancreatic islets: calcium extrusion by sodium-calcium countertransport.

9. Evidence for two distinct modalities of CA2+ influx into pancreatic B cell.

10. Regulation of 86Rb outflow from pancreatic islets: the dual effect of nutrient secretagogues.

1. Inosine partially mimics the effects of glucose on ionic fluxes, electrical activity, and insulin release in mouse pancreatic B-cells.

2. Binding of hypoglycaemic sulphonylureas to an artificial phospholipid bilayer.

3. Mathematical modelling of stimulus-secretion coupling in the pancreatic B-cell. I. Dynamics of insulin release.

4. Na+--K+ pump activity and the glucose-stimulated Ca2+-sensitive K+ permeability in the pancreatic B-cell.