Literature DB >> 6320565

Mathematical modelling of stimulus-secretion coupling in the pancreatic B-cell. I. Dynamics of insulin release.

Y Scholler, V De Maertelaer, W J Malaisse.   

Abstract

A mathematical model for cyclic AMP-Ca2+ interactions in pancreatic islets, defined in a previous study, was modified to include two new features. First, the cytosol and vacuolar Ca2+ pools were stratified in a cortical layer (representing 1 to 20% of the total cellular pool) and central core. Second, the changes in Ca2+ inflow and Ca2+ fractional outflow rate evoked by a rise in glucose concentration were discontinued during the 3rd and 4th min of stimulation. In this onion leaf sheet model, the biphasic pattern of glucose-induced insulin release could be simulated. This new model emphasizes the significance of both cytosol heterogeneity and signal discontinuity in the dynamics of insulin secretion.

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Year:  1983        PMID： 6320565     DOI： 10.1007/bf02581164

Source DB:  PubMed          Journal:  Acta Diabetol Lat        ISSN： 0001-5563


  12 in total

Review 1.  Regulation of calcium fluxes and their regulatory roles in pancreatic islets.

Authors:  W J Malaisse; A Herchuelz; G Devis; G Somers; A C Boschero; J C Hutton; S Kawazu; A Sener; I J Atwater; G Duncan; B Ribalet; E Rojas
Journal:  Ann N Y Acad Sci       Date:  1978-04-28       Impact factor: 5.691

2.  Pancreatic beta-cell web: its possible role in insulin secretion.

Authors:  L Orci; K H Gabbay; W J Malaisse
Journal:  Science       Date:  1972-03-10       Impact factor: 47.728

3.  The kinetics of electrical activity of beta cells in response to a "square wave" stimulation with glucose or glibenclamide.

Authors:  H P Meissner; I J Atwater
Journal:  Horm Metab Res       Date:  1976-01       Impact factor: 2.936

4.  Ionic determinants of bioelectrical spiking activity in the pancreatic B-cell.

Authors:  W J Malaisse; P Lebrun; A Herchuelz
Journal:  Pflugers Arch       Date:  1982-11-11       Impact factor: 3.657

5.  Intracellular calcium: its movement during pentylenetetrazole-induced bursting activity.

Authors:  E Sugaya; M Onozuka
Journal:  Science       Date:  1978-05-19       Impact factor: 47.728

6.  Calcium ion distribution in cytoplasm visualised by aequorin: diffusion in cytosol restricted by energized sequestering.

Authors:  B Rose; W R Loewenstein
Journal:  Science       Date:  1975-12-19       Impact factor: 47.728

7.  Regulation of calcium fluxes in pancreatic islets: dissociation between calcium and insulin release.

Authors:  A Herchuelz; W J Malaisse
Journal:  J Physiol       Date:  1978-10       Impact factor: 5.182

8.  Stimulus-secretion coupling of glucose-induced insulin release. Timing of early metabolic, ionic, and secretory events.

Authors:  W J Malaisse; A R Carpinelli; A Sener
Journal:  Metabolism       Date:  1981-05       Impact factor: 8.694

9.  The effect of glucose stimulation on 45calcium uptake of rat pancreatic islets and their total calcium content as measured by a fluorometric micro-method.

Authors:  G H Wolters; J B Wiegman; W Konijnendijk
Journal:  Diabetologia       Date:  1982-02       Impact factor: 10.122

10.  Mode of action of clonidine upon islet function: dissociated effects upon the time course and magnitude of insulin release.

Authors:  V Leclercq-Meyer; A Herchuelz; I Valverde; E Couturier; J Marchand; W J Malaisse
Journal:  Diabetes       Date:  1980-03       Impact factor: 9.461
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  2 in total

Review 1.  Kinetic aspects of compartmental storage and secretion of insulin and zinc.

Authors:  G Gold; G M Grodsky
Journal:  Experientia       Date:  1984-10-15

2.  Mathematical modeling of stimulus-secretion coupling in the pancreatic beta-cell. III. Glucose-induced inhibition of calcium efflux.

Authors:  Y Scholler; V De Maertelaer; W J Malaisse
Journal:  Biophys J       Date:  1984-10       Impact factor: 4.033
  2 in total

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