| Literature DB >> 675739 |
J P Rosazza, A W Nicholas, M E Gustafson.
Abstract
Microbial transformation experiments were conducted with the steroidlactone, withaferin-A (1a). Cunninghamella elegans (NRRL 1393) converts withaferin-A into two major metabolites, one of which has been indentified as 14alpha-hydroxywithaferin-A (1b). The metabolite is obtained in 37% yield, and its structure was determined on the basis of pmr and mass spectral evidence. The metabolite has the same level of antitumor activity as withaferin-A against the Sarcoma-180 tumor test system in mice.Entities:
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Year: 1978 PMID： 675739 DOI： 10.1016/s0039-128x(78)80007-5
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668