Literature DB >> 3583136

Microbiological and chemical dehydrogenation of withaferin A.

J Fuska, B Proska, J Williamson, J P Rosazza.   

Abstract

Arthrobacter simplex dehydrogenated withaferin A to 4-dehydrowithaferin A but it was not able to dehydrogenate this substrate in position 27. 27-Dehydrowithaferin A was prepared chemically using pyridinium chlorochromate. Whereas 4-dehydrowithaferin A surpassed in its effect on leukemic (388 cells the original compound and all its derivates synthesized so far, 27-dehydrowithaferin A was biologically inactive.

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Year:  1987        PMID： 3583136     DOI： 10.1007/bf02883237

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  5 in total

1.  Screening of the cytotoxic action of fungus filtrates on Ehrlich's ascites carcinoma, utilizing 14 C-labelled precursors.

Authors:  J Fuska; M Miko; P Nemec; L Drobnica
Journal:  Neoplasma       Date:  1971       Impact factor: 2.575

2.  Tumor inhibitors. XXXIX. Active principles of Acnistus arborescens. Isolation and structural and spectral studies of withaferin A and withacnistin.

Authors:  S M Kupchan; W K Anderson; P Bollinger; R W Doskotch; R M Smith; J A Renauld; H K Schnoes; A L Burlingame; D H Smith
Journal:  J Org Chem       Date:  1969-12       Impact factor: 4.354

3.  Novel cytotoxic and antitumor agents. IV. Withaferin A: relation of its structure to the in vitro cytotoxic effects on P388 cells.

Authors:  J Fuska; A Fusková; J P Rosazza; A W Nicholas
Journal:  Neoplasma       Date:  1984       Impact factor: 2.575

4.  Microbial transformations of natural antitumor agents. 23. Conversion of withaferin-A to 12 beta- and 15 beta-hydroxy derivatives of withaferin-A.

Authors:  J Fuska; J Prousek; J Rosazza; M Budesinsky
Journal:  Steroids       Date:  1982-08       Impact factor: 2.668

5.  Microbial transformations of natural antitumor agents. 7. 14-alpha-Hydroxylation of withaferin-A by Cunninghamella elegans (NRRL 1393).

Authors:  J P Rosazza; A W Nicholas; M E Gustafson
Journal:  Steroids       Date:  1978-05       Impact factor: 2.668
  5 in total
  2 in total

Review 1.  Withaferin A and its potential role in glioblastoma (GBM).

Authors:  Jasdeep Dhami; Edwin Chang; Sanjiv S Gambhir
Journal:  J Neurooncol       Date:  2016-11-11       Impact factor: 4.130

Review 2.  Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights.

Authors:  Yangliu Xia; Mingrui Yan; Ping Wang; Keisuke Hamada; Nana Yan; Haiping Hao; Frank J Gonzalez; Tingting Yan
Journal:  Drug Metab Dispos       Date:  2021-12-13       Impact factor: 3.579
  2 in total

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