| Literature DB >> 6753736 |
I P Thonus, P Fontijne, M F Michel.
Abstract
The killing rate induced by ampicillin was determined in 20 strains of Escherichia coli. The apparent generation rate constant for each E. coli showed a characteristic concentration-dependent course. This course can be mathematically described and is determined by four parameters. Three of these parameters determine the speed of the process, and the fourth parameter determines a minimal concentration. The susceptibility of the strains, measured as the minimal inhibitory concentration by an agar dilution method, correlated with the minimal concentration and with a minimal inhibitory concentration calculated from the curve, but not with the rate-determining parameters.Entities:
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Year: 1982 PMID: 6753736 PMCID: PMC183753 DOI: 10.1128/AAC.22.3.386
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191