Literature DB >> 6751241

Clinical response to therapy with thymopoietin pentapeptide (TP-5) in rheumatoid arthritis.

E M Veys, E C Huskisson, M Rosenthal, T L Vischer, H Mielants, P A Thrower, J Scott, H Ott, H Scheijgrond, J Symoens.   

Abstract

The effect of thymopoietin pentapeptide (TP-5) was evaluated in patients with rheumatoid arthritis (RA). Ninety-two patients were divided into 3 groups, namely, placebo, TP-5 intramuscularly (IM) 1 mg, TP-5 intravenously (IV) 50 mg, and were evaluated for 6 measures of disease activity at the beginning of the study and at 3 and 6 months. No difference was observed between the placebo group and the group treated with TP-5 IM 1 mg. However, in the group treated with TP-5 IV 50 mg a statistically significant improvement of all parameters except the ESR was observed.

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Year:  1982        PMID: 6751241      PMCID: PMC1001017          DOI: 10.1136/ard.41.5.441

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN: 0003-4967            Impact factor:   19.103


  10 in total

Review 1.  Immunopathogenesis of rheumatoid arthritis.

Authors:  S A Paget; A Gibofsky
Journal:  Am J Med       Date:  1979-12       Impact factor: 4.965

2.  The generation and regulation of lymphocyte populations: evidence from differentiative induction systems in vitro.

Authors:  M P Scheid; G Goldstein; E A Boyse
Journal:  J Exp Med       Date:  1978-06-01       Impact factor: 14.307

3.  Induction of T-cell differentiation in vitro by thymin, a purified polypeptide hormone of the thymus.

Authors:  R S Basch; G Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1974-04       Impact factor: 11.205

4.  Measurement of pain.

Authors:  E C Huskisson
Journal:  Lancet       Date:  1974-11-09       Impact factor: 79.321

5.  Isolation of bovine thymin: a polypeptide hormone of the thymus.

Authors:  G Goldstein
Journal:  Nature       Date:  1974-01-04       Impact factor: 49.962

6.  Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis.

Authors:  D M Ritchie; J A Boyle; J M McInnes; M K Jasani; T G Dalakos; P Grieveson; W W Buchanan
Journal:  Q J Med       Date:  1968-07

7.  A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin.

Authors:  G Goldstein; M P Scheid; E A Boyse; D H Schlesinger; J Van Wauwe
Journal:  Science       Date:  1979-06-22       Impact factor: 47.728

8.  Levamisole in rheumatoid arthritis--a multivariate analysis of a multicentric study.

Authors:  P J Lewi; J Symoens
Journal:  J Rheumatol Suppl       Date:  1978

9.  Short in vitro half-life of thymopoietin32--36 pentapeptide in human plasma.

Authors:  J P Tischio; J E Patrick; H S Weintraub; M Chasin; G Goldstein
Journal:  Int J Pept Protein Res       Date:  1979

10.  Comparison of azathioprine, cyclophosphamide, and gold in treatment of rheumatoid arthritis.

Authors:  H L Currey; J Harris; R M Mason; J Woodland; T Beveridge; C J Roberts; D W Vere; A S Dixon; J Davies; B Owen-Smith
Journal:  Br Med J       Date:  1974-09-28
  10 in total
  5 in total

1.  Thymopentin: stability considerations and potency by various routes of administration.

Authors:  T K Audhya; G Goldstein
Journal:  Surv Immunol Res       Date:  1985

2.  Confirmative study of the effectiveness of thymopentin in active rheumatoid arthritis.

Authors:  M Malaise; P Franchimont; C Hauwaert; B Danneskiold-Samsoe; D Gross; H Gerber; H Gerschpacher; K Bolla
Journal:  Surv Immunol Res       Date:  1985

3.  Some observations on various dose regimens of thymopentin treatment in rheumatoid arthritis.

Authors:  L Molin; F Schmid; K Bolla
Journal:  Surv Immunol Res       Date:  1985

4.  Effects of the immunomodulator diacetyl-splenopentin on antigen-induced arthritis in rabbits.

Authors:  R Bräuer; K Thoss; S Henzgen; G Waldmann
Journal:  Agents Actions       Date:  1992-01

Review 5.  Thymopentin and splenopentin as immunomodulators. Current status.

Authors:  V K Singh; S Biswas; K B Mathur; W Haq; S K Garg; S S Agarwal
Journal:  Immunol Res       Date:  1998       Impact factor: 2.829

  5 in total

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