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Literature DB >> 4545430

Induction of T-cell differentiation in vitro by thymin, a purified polypeptide hormone of the thymus.

Abstract

Thymin, a purified polypeptide isolated from bovine thymus, was shown to induce the expression of differentiation antigens characteristic of thymocytes [TL and Thy-1 (theta)] when incubated in vitro with mouse bone marrow or spleen cells. This induction occurred in 5-10% of the cells from bone marrow after a 2-hr incubation with subnanogram concentrations of thymin. The induced cells expressed more TL and Thy-1 (theta) antigens than average normal thymocytes.

Entities: Gene Species

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Year: 1974 PMID： 4545430 PMCID： PMC388252 DOI： 10.1073/pnas.71.4.1474

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. Studies on experimental autoimmune thymitis in guinea-pigs.

Authors: J R Kalden; W G Williamson; R J Johnston; W J Irvine
Journal: Clin Exp Immunol Date: 1969-10 Impact factor: 4.330

2. Experimental autoimmune thymitis. An animal model of human myasthenia gravis.

Authors: G Goldstein; S Whittingham
Journal: Lancet Date: 1966-08-06 Impact factor: 79.321

3. Appearance of T-cell markers in bone marrow rosette-forming cells after incubation with thymosin, a thymic hormone.

Authors: J F Bach; M Dardenne; A L Goldstein; A Guha; A White
Journal: Proc Natl Acad Sci U S A Date: 1971-11 Impact factor: 11.205

4. The thymus, thymosin and anti-thymosin.

Authors: G Goldstein
Journal: Vox Sang Date: 1970-08 Impact factor: 2.144

5. ABC of endocrinology. I. Hormones in general.

Authors: K J Catt
Journal: Lancet Date: 1970-04-11 Impact factor: 79.321

6. Thymin: a thymic polypeptide causing the neuromuscular block of myasthenia gravis.

Authors: G Goldstein; A Manganaro
Journal: Ann N Y Acad Sci Date: 1971-09-15 Impact factor: 5.691

7. Endocrine function of the thymus affecting neuromuscular transmission.

Authors: G Goldstein; W W Hofmann
Journal: Clin Exp Immunol Date: 1969-02 Impact factor: 4.330

8. A cytological study of the capacity for differentiation of normal hemopoietic colony-forming cells.

Authors: A M Wu; J E Till; L Siminovitch; E A McCulloch
Journal: J Cell Physiol Date: 1967-04 Impact factor: 6.384

9. The thymus and neuromuscular function. A substance in thymus which causes myositis and myasthenic neuromuscular block in guineapigs.

Authors: G Goldstein
Journal: Lancet Date: 1968-07-20 Impact factor: 79.321

10. Thymitis and myasthenia gravis.

Authors: G Goldstein
Journal: Lancet Date: 1966-11-26 Impact factor: 79.321

31 in total

1. In vitro differentiation of human marrow cells into T lymphocytes by thymic extracts using the rosette technique.

Authors: G S Incefy; P L'Esperance; R A Good
Journal: Clin Exp Immunol Date: 1975-03 Impact factor: 4.330

2. Interferon: purification and initial characterization from human diploid cells.

Authors: E Knight
Journal: Proc Natl Acad Sci U S A Date: 1976-02 Impact factor: 11.205

3. Rosette formation by human T and B lymphocytes in the presence of adrenergic and cholinergic drugs.

Authors: G G Ferreira; H K Brascher; M Q Javierre; W A Sassine; A O Lima
Journal: Experientia Date: 1976-12-15

4. Three distinct human thymopoietins are derived from alternatively spliced mRNAs.

Authors: C A Harris; P J Andryuk; S Cline; H K Chan; A Natarajan; J J Siekierka; G Goldstein
Journal: Proc Natl Acad Sci U S A Date: 1994-07-05 Impact factor: 11.205

5. Restoration of suppressor function in athymic mice.

Authors: W J Hopkins
Journal: Immunology Date: 1978-02 Impact factor: 7.397

6. Arg-Lys-Asp-Val-Tyr (thymopentin) accelerates the cholinergic-induced inactivation (desensitization) of reconstituted nicotinic receptor.

Authors: E L Ochoa; S Medrano; M C de Carlin; A M Dilonardo
Journal: Cell Mol Neurobiol Date: 1988-09 Impact factor: 5.046