Literature DB >> 6748163

Modulation of hepatitis B infection by intravenous application of an immunoglobulin preparation that contains antibodies to hepatitis B e and core antigens but not to hepatitis B surface antigen.

W Stephan, A M Prince, B Brotman.   

Abstract

Repeated administration of an intravenous immunoglobulin containing antibody to hepatitis B e antigen (anti-HBe) and antibody to hepatitis B core antigen (anti-HBc) but free of antibody to hepatitis B surface antigen (anti-HBs) before and after the inoculation of 10(4.9) 50% chimpanzee infective doses of hepatitis B virus (HBV) markedly prolonged the incubation period of HBV in experimentally infected chimpanzees. Similar administration of an immunoglobulin preparation containing anti-HBc but free of anti-HBe and anti-HBs or intramuscular administration of a single dose of immunoglobulin containing anti-HBe and anti-HBc 3 days before or after inoculation with HBV did not appear to modulate HBV infection. These observations suggested that anti-HBe, or an unidentified antibody associated with it, may have biological activity in the modulation of HBV replication.

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Year:  1984        PMID： 6748163      PMCID： PMC254454          DOI： 10.1128/JVI.51.2.420-424.1984

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  13 in total

1.  Demonstration of hepatitis B e antigen in the core of Dane particles.

Authors:  K Takahashi; Y Akahane; T Gotanda; T Mishiro; M Imai; Y Miyakawa; M Mayumi
Journal:  J Immunol       Date:  1979-01       Impact factor: 5.422

2.  The isolation of gamma globulin from blood-serum by rivanol.

Authors:  J HOREJSI; R SMETANA
Journal:  Acta Med Scand       Date:  1956-06-30

3.  [Elimination of complement fixation of gamma-globulin by chemical modification with beta-propiolactone].

Authors:  W Stephan
Journal:  Z Klin Chem Klin Biochem       Date:  1969-05

4.  Association of hepatitis B e-antigen (HBeAg) determinants with the core of Dane particles.

Authors:  A R Neurath; N Strick
Journal:  J Gen Virol       Date:  1979-03       Impact factor: 3.891

5.  beta-propiolactone/ultraviolet irradiation: a review of its effectiveness for inactivation of viruses in blood derivatives.

Authors:  A M Prince; W Stephan; B Brotman
Journal:  Rev Infect Dis       Date:  1983 Jan-Feb

6.  Quantitation of circulating immune complexes by combined PEG precipitation and immunoglobulin-specific radioimmunoassay (PICRIA).

Authors:  H C Siersted; I Brandslund; S E Svehag; J C Jensenius
Journal:  Methods Enzymol       Date:  1981       Impact factor: 1.600

7.  Core antigen-specific immunoglobulin G bound to the liver cell membrane in chronic hepatitis B.

Authors:  A Trevisan; G Realdi; A Alberti; G Ongaro; E Pornaro; R Meliconi
Journal:  Gastroenterology       Date:  1982-02       Impact factor: 22.682

8.  Inactivation of hepatitis B and non-A, non-B viruses by combined use of Tween 80, beta-propiolactone, and ultraviolet irradiation.

Authors:  A M Prince; W Stephan; R Kotitschke; B Brotman
Journal:  Thromb Haemost       Date:  1983-08-30       Impact factor: 5.249

9.  Use of and interpretation of results using inocula of hepatitis B virus with known infectivity titers.

Authors:  E Tabor; R H Purcell; W T London; R J Gerety
Journal:  J Infect Dis       Date:  1983-03       Impact factor: 5.226

10.  [Prophylaxis and therapy with gamma globulin. General characterization and clinical use of gamma globulin preparations].

Authors:  S Barandun; F Skvaril; A Morell
Journal:  Schweiz Med Wochenschr       Date:  1976-04-17
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  8 in total

Review 1.  Immunopathogenesis of viral hepatitis.

Authors:  M U Mondelli
Journal:  Clin Rev Allergy Immunol       Date:  2000-04       Impact factor: 8.667

Review 2.  The chimpanzee model for hepatitis B virus infection.

Authors:  Stefan F Wieland
Journal:  Cold Spring Harb Perspect Med       Date:  2015-06-01       Impact factor: 6.915

Review 3.  Hepatitis B virus immunopathology.

Authors:  F V Chisari; C Ferrari
Journal:  Springer Semin Immunopathol       Date:  1995

4.  The affinity of anti-HBc antibodies in acute and chronic hepatitis B infection.

Authors:  Y M Wen; S C Duan; C R Howard; A F Frew; M W Steward
Journal:  Clin Exp Immunol       Date:  1990-01       Impact factor: 4.330

5.  The secretory core protein of human hepatitis B virus is expressed on the cell surface.

Authors:  H J Schlicht; H Schaller
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

6.  Hepatitis B e Antigen Seroconversion Is Related with the Function of Dendritic Cells in Chronic Hepatitis B Virus Infection.

Authors:  Chunjing Lin; Hai Zou; Shumin Wang
Journal:  Gastroenterol Res Pract       Date:  2014-12-09       Impact factor: 2.260

7.  The HBV HBX gene expressed in E. coli is recognised by sera from hepatitis patients.

Authors:  A Kay; E Mandart; C Trepo; F Galibert
Journal:  EMBO J       Date:  1985-05       Impact factor: 11.598

8.  Outcome of Intravenous Immunoglobulin-Transmitted HTLV-I, Hepatitis B, Hepatitis C, and HIV infections.

Authors:  Mohsen Foroughipour; Farahzad Jabbari Azad; Reza Farid Hosseini; Abbas Shirdel; Amir Reza Khalighi; Hadis Yousefzadeh; Homa Sadri; Toktam Moghiman; Hossein Hekmatkhah
Journal:  Iran J Basic Med Sci       Date:  2013-03       Impact factor: 2.699
  8 in total

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