Literature DB >> 6745220

Development and persistence of kindled seizures after repeated injections of pentylenetetrazol in rats and guinea pigs.

R G Diehl, A Smialowski, T Gotwo.   

Abstract

Pentylenetetrazol (PTZ) was injected into rats (30 or 35 mg/kg) and guinea pigs (40 or 45 mg/kg) daily or every second day. A progressive development of seizure activity after this treatment was observed. Doses ineffective after the first injection induced tonic seizures after 20 injections. Both kinds of treated animals immediately developed tonic seizures when PTZ was injected after a few months interruption for one time only. The results support the assumption that seizures induced by chronic injection of PTZ are similar to kindled seizures evoked by daily electrical stimulation and can be regarded as a model of epileptogenesis.

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Year:  1984        PMID： 6745220     DOI： 10.1111/j.1528-1157.1984.tb03452.x

Source DB:  PubMed          Journal:  Epilepsia        ISSN： 0013-9580            Impact factor:   5.864


  10 in total

1.  Effect of coriaria lactone-activated astrocyte-conditioned medium on the cerebral TNF-alpha of normal rats.

Authors:  Zhongyu Li; Qingying Liu; Changgeng Zhu; Wei Wang
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2006

2.  Changes in behavior and amino acid neurotransmitters in the brain of rats with seizure induced by IL-1beta or IL-6.

Authors:  Zhu Xiaoqin; Li Zhengli; Zhu Changgeng; Wang Xiaojing; Li Li
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2005

3.  [Vildagliptin suppresses temporal lobe epilepsy by up-regulating glucagon-like peptide-1].

Authors:  Yue-Tao Wen; Kun-Lun Wu; Quan-Hong Shi
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2017-01-20

4.  Effects of chloroquine on GFAP, PCNA and cyclin D1 in hippocampus and cerebral cortex of rats with seizures induced by pentylenetetrazole.

Authors:  Shuhua Zhang; Changgeng Zhu; Qingying Liu; Wei Wang
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2005

5.  Ferulic Acid Supplementation for Management of Depression in Epilepsy.

Authors:  Tanveer Singh; Taranjot Kaur; Rajesh Kumar Goel
Journal:  Neurochem Res       Date:  2017-06-12       Impact factor: 3.996

6.  Expression of AMPA receptor subunits in hippocampus after status convulsion.

Authors:  Yue Hu; Li Jiang; Hengsheng Chen; XiaoPing Zhang
Journal:  Childs Nerv Syst       Date:  2012-04-15       Impact factor: 1.475

7.  Variations of rat brain calmodulin content in dark and light phases: effect of pentylenetetrazol-induced kindling.

Authors:  M Asai; G Benítez-King
Journal:  Neurochem Res       Date:  1998-09       Impact factor: 3.996

8.  Lentiviral Vector-Induced Overexpression of RGMa in the Hippocampus Suppresses Seizures and Mossy Fiber Sprouting.

Authors:  Ling Chen; Baobing Gao; Min Fang; Jie Li; Xiujuan Mi; Xin Xu; Wei Wang; Juan Gu; Bo Tang; Yanke Zhang; Zhihua Wang; Ao Zhan; Guojun Chen; Xuefeng Wang
Journal:  Mol Neurobiol       Date:  2016-02-03       Impact factor: 5.590

9.  [(18)F]FDG PET Neuroimaging Predicts Pentylenetetrazole (PTZ) Kindling Outcome in Rats.

Authors:  Pablo Bascuñana; Julián Javela; Mercedes Delgado; Rubén Fernández de la Rosa; Ahmed Anis Shiha; Luis García-García; Miguel Ángel Pozo
Journal:  Mol Imaging Biol       Date:  2016-10       Impact factor: 3.488

10.  Relative Safety of Different Antidepressants for Treatment of Depression in Chronic Epileptic Animals Associated with Depression.

Authors:  Rakesh Kumar Sharma; Tanveer Singh; Awanish Mishra; Rajesh Kumar Goel
Journal:  J Epilepsy Res       Date:  2017-06-30
  10 in total

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