Literature DB >> 6744675

Specificity of anti-type II collagen antibody response in rats.

K Kakimoto, T Hirofuji, T Koga.   

Abstract

Specificity of the rat antibody against type II collagen was investigated using rat, bovine and human type II collagen preparations. PVG/c rats showed the highest antibody level in assays with autologous rat type II collagen than with heterologous (bovine or human) type II collagen even when immunized with heterologous one. On the other hand, the rat exhibited significantly low antibody response when they were immunized with autologous type II collagen. The results indicate that rats develop strong antibody response against self type II collagen when immunized with heterologous collagen and this unique specificity of anti-type II collagen antibody response suggests that autoimmunity is involved in the pathogenesis of collagen-induced arthritis in rats.

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Year:  1984        PMID： 6744675      PMCID： PMC1536100     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  19 in total

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Authors:  E J Miller
Journal:  Biochemistry       Date:  1972-12-19       Impact factor: 3.162

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Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

3.  Suppressor T cells prevent experimental autoimmune encephalomyelitis in mice.

Authors:  C C Bernard
Journal:  Clin Exp Immunol       Date:  1977-07       Impact factor: 4.330

4.  Induction and termination of immunologic tolerance to protein antigens.

Authors:  W O Weigle
Journal:  Fed Proc       Date:  1966 Jan-Feb

5.  Immunisation against heterologous type II collagen induces arthritis in mice.

Authors:  J S Courtenay; M J Dallman; A D Dayan; A Martin; B Mosedale
Journal:  Nature       Date:  1980-02-14       Impact factor: 49.962

6.  Humoral and cellular sensitivity to collagen in type II collagen-induced arthritis in rats.

Authors:  D E Trentham; A S Townes; A H Kang; J R David
Journal:  J Clin Invest       Date:  1978-01       Impact factor: 14.808

7.  Native type II collagen-induced arthritis in the rat. I. Incidence and humoral response to collagen.

Authors:  K Morgan; R B Clague; M J Shaw; P J Holt
Journal:  Ann Rheum Dis       Date:  1980-06       Impact factor: 19.103

8.  Efficient induction of collagen arthritis by the use of a synthetic muramyl dipeptide.

Authors:  T Koga; S Sakamoto; K Onoue; S Kotani; A Sumiyoshi
Journal:  Arthritis Rheum       Date:  1980-09

9.  Autoimmunity to type II collagen an experimental model of arthritis.

Authors:  D E Trentham; A S Townes; A H Kang
Journal:  J Exp Med       Date:  1977-09-01       Impact factor: 14.307

10.  The production of thyroiditis and antibody following injection of unaltered thyroglobulin without adjuvant into rabbits previously stimulated with altered thyroglobulin.

Authors:  W O Weigle
Journal:  J Exp Med       Date:  1965-12-01       Impact factor: 14.307
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  3 in total

1.  The effect of treatment with interferon-gamma on type II collagen-induced arthritis.

Authors:  H Nakajima; H Takamori; Y Hiyama; W Tsukada
Journal:  Clin Exp Immunol       Date:  1990-09       Impact factor: 4.330

2.  Epitope specificity of antibody response against human type II collagen in the mouse susceptible to collagen-induced arthritis and patients with rheumatoid arthritis.

Authors:  H Iribe; H Kabashima; Y Ishii; T Koga
Journal:  Clin Exp Immunol       Date:  1988-09       Impact factor: 4.330

3.  Cell-mediated transfer of collagen-induced arthritis in mice and its application to the analysis of the inhibitory effects of interferon-gamma and cyclophosphamide.

Authors:  H Nakajima; Y Hiyama; H Takamori; W Tsukada
Journal:  Clin Exp Immunol       Date:  1993-05       Impact factor: 4.330
  3 in total

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