Literature DB >> 6744475

Preparation of antitumor platinum(II) complexes of 1,2-diphenylethylenediamine isomers and their interactions with DNA and its purine moieties.

M Noji, Y Gohchi, Y Kidani.   

Abstract

A series of Pt(II) complexes containing 1,2-diphenylethylenediamine (stien) isomers were synthesized and tested for their antitumor activity against leukemia L1210. Among the Pt(II) complexes examined water-soluble Pt(II) complexes with sulfate, nitrate and D-glucuronate ions as leaving groups exhibited relatively high antitumor activity. Furthermore, the interactions between calf-thymus DNA and Pt(SO4) (stein) complexes were investigated by means of circular dichroism spectrometry. Dichroism enhancements observed in the interaction between DNA and Pt(SO4) (stien) complexes were analysed to be contributable to two factors: (1) vicinal effects of DNA on the d-d transitions of Pt(II) ions and (2) conformational changes of DNA caused by the coordination of cis-configurational Pt(II) complexes.

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Year:  1984        PMID： 6744475     DOI： 10.1016/0009-2797(84)90018-8

Source DB:  PubMed          Journal:  Chem Biol Interact        ISSN： 0009-2797            Impact factor:   5.192


  6 in total

1.  [1,2-Bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer. II. Synthesis and preliminary testing of the enantiomeric complexes.

Authors:  G Bernhardt; R Gust; H Reile; H D vom Orde; R Müller; C Keller; T Spruss; H Schönenberger; T Burgemeister; A Mannschreck
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

2.  Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. V. Synthesis and evaluation of enantiomeric [1,2-bis-(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes.

Authors:  H D vom Orde; H Reile; R Müller; R Gust; G Bernhardt; T Spruss; H Schönenberger; T Burgemeister; A Mannschreck
Journal:  J Cancer Res Clin Oncol       Date:  1990       Impact factor: 4.553

3.  Chemosensitivity of human MCF-7 breast cancer cells to diastereoisomeric diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and specific platinum accumulation.

Authors:  H Reile; G Bernhardt; M Koch; H Schönenberger; M Hollstein; F Lux
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

4.  Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes.

Authors:  M Jennerwein; B Wappes; R Gust; H Schönenberger; J Engel; S Seeber; R Osieka
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

Review 5.  Advances in platinum cancer chemotherapy. Advances in the design of cisplatin analogues.

Authors:  P C Hydes; M J Russell
Journal:  Cancer Metastasis Rev       Date:  1988-04       Impact factor: 9.264

Review 6.  Chiral discrimination in platinum anticancer drugs.

Authors:  Michele Benedetti; Jaroslav Malina; Jana Kasparkova; Viktor Brabec; Giovanni Natile
Journal:  Environ Health Perspect       Date:  2002-10       Impact factor: 9.031
  6 in total

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