Literature DB >> 3410875

Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes.

M Jennerwein1, B Wappes, R Gust, H Schönenberger, J Engel, S Seeber, R Osieka.   

Abstract

Diastereomeric para-substituted dichloro(1,2-diphenylethylenediamine)platinum(II) complexes were synthesized and tested for their antitumor activity on the human MDA-MB 231 breast cancer cell line and the P 388 leukemia of the mouse. An interaction with the DNA was demonstrated by UV difference spectroscopy. The D,L configurated, 4-fluoro-substituted complex was the most active.

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Year:  1988        PMID： 3410875     DOI： 10.1007/bf02128177

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  9 in total

1.  Effects of estrone, estradiol, and estriol on hormone-responsive human breast cancer in long-term tissue culture.

Authors:  M Lippman; M E Monaco; G Bolan
Journal:  Cancer Res       Date:  1977-06       Impact factor: 12.701

2.  Ring-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum (II) complexes: compounds with a selective effect on the hormone-dependent mammary carcinoma.

Authors:  J Karl; R Gust; T Spruss; M R Schneider; H Schönenberger; J Engel; K H Wrobel; F Lux; S T Haeberlin
Journal:  J Med Chem       Date:  1988-01       Impact factor: 7.446

3.  [Configurative assignment of the diastereomer N,N'-dialkyl- , '-diphenylethylenediamines by nucleic resonance spectroscopy. 19. Cytostatics].

Authors:  R Schönenberger; C Sunkel; H Schönenberger
Journal:  Arzneimittelforschung       Date:  1972-11

4.  The tumor-inhibiting effect of isomeric dichloro(diphenylethylenediamine)platinum(II) complexes.

Authors:  B Wappes; M Jennerwein; E von Angerer; J Engel; H Schönenberger; H Brunner; M Schmidt; M Berger; D Schmähl; S Seeber
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553

5.  In vivo resistance towards anthracyclines, etoposide, and cis-diamminedichloroplatinum(II).

Authors:  S Seeber; R Osieka; C G Schmidt; W Achterrath; S T Crooke
Journal:  Cancer Res       Date:  1982-11       Impact factor: 12.701

6.  Dichloro[1,2-bis(4-hydroxyphenyl)ethylenediamine]platinum(II) complexes: an approach to develop compounds with a specific effect on the hormone-dependent mammary carcinoma.

Authors:  B Wappes; M Jennerwein; E von Angerer; H Schönenberger; J Engel; M Berger; K H Wrobel
Journal:  J Med Chem       Date:  1984-10       Impact factor: 7.446

7.  Preparation of antitumor platinum(II) complexes of 1,2-diphenylethylenediamine isomers and their interactions with DNA and its purine moieties.

Authors:  M Noji; Y Gohchi; Y Kidani
Journal:  Chem Biol Interact       Date:  1984-09-01       Impact factor: 5.192

8.  Synthesis of platinum(II) complexes of 4-substituted o-phenylenediamine derivatives and determination of their antitumor activity.

Authors:  Y Kidani; Y Asano; M Noji
Journal:  Chem Pharm Bull (Tokyo)       Date:  1979-11       Impact factor: 1.645

9.  Mutagenicity of substituted (o-phenylenediamine)platinum dichloride in the Ames test. A quantitative structure-activity analysis.

Authors:  C Hansch; B H Venger; A Panthananickal
Journal:  J Med Chem       Date:  1980-04       Impact factor: 7.446
  9 in total
  2 in total

1.  NMR structure of a complex between MDM2 and a small molecule inhibitor.

Authors:  David C Fry; S Donald Emerson; Stefan Palme; Binh T Vu; Chao-Min Liu; Frank Podlaski
Journal:  J Biomol NMR       Date:  2004-10       Impact factor: 2.835

2.  [N,N'-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties.

Authors:  Annegret Hille; Ingo Ott; Ana Kitanovic; Igor Kitanovic; Hamed Alborzinia; Elke Lederer; Stefan Wölfl; Nils Metzler-Nolte; Sven Schäfer; William S Sheldrick; Caroline Bischof; Ulrich Schatzschneider; Ronald Gust
Journal:  J Biol Inorg Chem       Date:  2009-03-04       Impact factor: 3.358
  2 in total

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