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Literature DB >> 6743487

Pharmacodynamics and pharmacokinetics of digoxin in the presence of lithium.

S J Cooper, J G Kelly, G D Johnston, S Copeland, D J King, D G McDevitt.

Abstract

Previous biochemical and clinical data suggest there may be an interaction between digoxin and lithium. The pharmacodynamics and pharmacokinetics of an intravenous infusion of digoxin were studied in six male subjects before and after 2 weeks treatment with lithium carbonate. The effects of lithium on sodium pump activity, intracellular electrolytes and extracellular electrolytes were studied. No significant interaction between digoxin and lithium was found. No significant effects of lithium on sodium pump activity or electrolyte concentrations were found.

Entities: Chemical

Mesh：

Substances：

Year: 1984 PMID： 6743487 PMCID： PMC1463587 DOI： 10.1111/j.1365-2125.1984.tb05016.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

16 in total

1. The 24-hour lithium level as a prognosticator of dosage requirements: a 2-year follow-up study.

Authors: T B Cooper; G M Simpson
Journal: Am J Psychiatry Date: 1976-04 Impact factor: 18.112

Review 2. Is the cell membrane Na+, K+ -ATPase enzyme system the pharmacological receptor for digitalis?

Authors: A Schwartz
Journal: Circ Res Date: 1976-07 Impact factor: 17.367

3. Effects of lithium and thallous ions on sodium pump activity in the guinea-pig heart and their relationship to the positive inotropic action.

Authors: D D Ku; T Akera; M K Olgaard; T M Brody
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1978-09 Impact factor: 3.000

4. Mineral metabolism in affective disorders.

Authors: A Coppen
Journal: Br J Psychiatry Date: 1965-12 Impact factor: 9.319

5. Erythrocyte membrane cation carrier in manic-depressive psychosis.

Authors: G J Naylor; A H Smith; E G Dick; D A Dick; A M McHarg; C A Chambers
Journal: Psychol Med Date: 1980-08 Impact factor: 7.723

6. Effect of lithium on cardiovascular performance: report on extended ambulatory monitoring and exercise testing before and during lithium therapy.

Authors: A G Tilkian; J S Schroeder; J Kao; H Hultgren
Journal: Am J Cardiol Date: 1976-11-23 Impact factor: 2.778

Pharmacodynamics and pharmacokinetics of digoxin in the presence of lithium.

1. The 24-hour lithium level as a prognosticator of dosage requirements: a 2-year follow-up study.

Review 2. Is the cell membrane Na+, K+ -ATPase enzyme system the pharmacological receptor for digitalis?

3. Effects of lithium and thallous ions on sodium pump activity in the guinea-pig heart and their relationship to the positive inotropic action.

4. Mineral metabolism in affective disorders.

5. Erythrocyte membrane cation carrier in manic-depressive psychosis.

6. Effect of lithium on cardiovascular performance: report on extended ambulatory monitoring and exercise testing before and during lithium therapy.

7. Effect of electroconvulsive therapy on erythrocyte adenosine triphosphatase activity in depressive illness.

8. Lithium and erythrocyte membrane cation carrier studies in normal and manic depressive subjects.

9. Activity of erythrocyte Na,K-ATPase in manic patients.

10. Erythrocyte membrane cation carrier, relapse rate of manic-depressive illness and response to lithium.

Review 1. Differential pharmacokinetics of digoxin in elderly patients.