Literature DB >> 3919750

Calcium antagonists stimulate sperm motility in ejaculated human semen.

C Y Hong, B N Chiang, J Ku, Y H Wei, J C Fong.   

Abstract

Three calcium antagonists, diltiazem, flunarizine and verapamil stimulated human sperm motility in vitro. Among them, diltiazem induced the largest amplitude of motility increase. The concentration-response curve of diltiazem was similar in shape to those of calcium chelators. EGTA, a calcium chelator, potentiated the stimulatory effect of diltiazem while A23187, a calcium ionophore, antagonized it. These observations supported our previous hypothesis that an increased concentration of calcium ion was detrimental to human sperm motility. Whether calcium antagonists could be used in the treatment of subfertile patients awaits further investigation.

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Year:  1985        PMID： 3919750      PMCID： PMC1463801          DOI： 10.1111/j.1365-2125.1985.tb02611.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  16 in total

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Authors:  T T Turner
Journal:  Invest Urol       Date:  1979-03

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Authors:  B Morton; J Harrigan-Lum; L Albagli; T Jooss
Journal:  Biochem Biophys Res Commun       Date:  1974-01-23       Impact factor: 3.575

3.  Influence of lipid solubility on the sperm immobilizing effect of beta-adrenoceptor blocking drugs.

Authors:  C Y Hong; P Turner
Journal:  Br J Clin Pharmacol       Date:  1982-08       Impact factor: 4.335

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Authors:  R D Amelar; L Dubin; C Schoenfeld
Journal:  Fertil Steril       Date:  1980-09       Impact factor: 7.329

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Authors:  S Arver
Journal:  Acta Physiol Scand Suppl       Date:  1982

6.  Local anaesthetic effect of antiarrhythmic drugs and human sperm immobilization: mechanism and application of the interrelationship.

Authors:  C Y Hong; B N Chiang
Journal:  Br J Clin Pharmacol       Date:  1984-06       Impact factor: 4.335

7.  Observations on the motility, ultrastructure and elemental composition of human spermatozoa incubated with caffeine.

Authors:  R F Harrison; B L Sheppard; M Kaliszer
Journal:  Andrologia       Date:  1980 Jan-Feb       Impact factor: 2.775

8.  A simple method to measure drug effects on human sperm motility.

Authors:  C Y Hong; D M Chaput de Saintonge; P Turner
Journal:  Br J Clin Pharmacol       Date:  1981-04       Impact factor: 4.335

9.  Intermittent swimming in live sea urchin sperm.

Authors:  B H Gibbons
Journal:  J Cell Biol       Date:  1980-01       Impact factor: 10.539

10.  Calcium-induced quiescence in reactivated sea urchin sperm.

Authors:  B H Gibbons; I R Gibbons
Journal:  J Cell Biol       Date:  1980-01       Impact factor: 10.539
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  10 in total

1.  Ca2+ ionophore A23187 can make mouse spermatozoa capable of fertilizing in vitro without activation of cAMP-dependent phosphorylation pathways.

Authors:  Hiroyuki Tateno; Dario Krapf; Toshiaki Hino; Claudia Sánchez-Cárdenas; Alberto Darszon; Ryuzo Yanagimachi; Pablo E Visconti
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-15       Impact factor: 11.205

2.  Involvement of calcium in the caffeine stimulation of human sperm motility.

Authors:  C Y Hong; B N Chiang; P Wu; Y H Wei; J C Fong
Journal:  Br J Clin Pharmacol       Date:  1985-06       Impact factor: 4.335

3.  A modified trans-membrane migration method for measuring the effect of drugs on sperm motility.

Authors:  N T Raoof; R M Pearson; P Turner
Journal:  Br J Clin Pharmacol       Date:  1987-09       Impact factor: 4.335

Review 4.  The effects of drugs on sperm.

Authors:  J O Drife
Journal:  Drugs       Date:  1987-06       Impact factor: 9.546

5.  Suppression of snake-venom cardiotoxin-induced cardiomyocyte degeneration by blockage of Ca2+ influx or inhibition of non-lysosomal proteinases.

Authors:  W F Tzeng; Y H Chen
Journal:  Biochem J       Date:  1988-11-15       Impact factor: 3.857

Review 6.  Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction.

Authors:  Reyon Dcunha; Reda S Hussein; Hanumappa Ananda; Sandhya Kumari; Satish Kumar Adiga; Nagarajan Kannan; Yulian Zhao; Guruprasad Kalthur
Journal:  Reprod Sci       Date:  2020-12-07       Impact factor: 3.060

Review 7.  Drugs in semen.

Authors:  S Pichini; P Zuccaro; R Pacifici
Journal:  Clin Pharmacokinet       Date:  1994-05       Impact factor: 6.447

8.  Pentoxifylline stimulates human sperm motility both in vitro and after oral therapy.

Authors:  M R Shen; P H Chiang; R C Yang; C Y Hong; S S Chen
Journal:  Br J Clin Pharmacol       Date:  1991-06       Impact factor: 4.335

9.  Identification and function of exchange proteins activated directly by cyclic AMP (Epac) in mammalian spermatozoa.

Authors:  Alvaro Miro-Moran; Isaac Jardin; Cristina Ortega-Ferrusola; Gines M Salido; Fernando J Peña; Jose A Tapia; Ines M Aparicio
Journal:  PLoS One       Date:  2012-05-25       Impact factor: 3.240

10.  Coupling of TRPV6 and TMEM16A in epithelial principal cells of the rat epididymis.

Authors:  Da Yuan Gao; Bao Li Zhang; Matthew C T Leung; Simon C L Au; Patrick Y D Wong; Winnie W C Shum
Journal:  J Gen Physiol       Date:  2016-08       Impact factor: 4.086
  10 in total

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