Literature DB >> 6740330

Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor.

S F Josephs, L Ratner, M F Clarke, E H Westin, M S Reitz, F Wong-Staal.   

Abstract

The nucleotide sequence of a transforming human c-sis complementary DNA shows an open reading frame 723 base pairs in length located downstream from an in-phase terminator thymine-guanine-adenine codon. Sequences within this region were identical to those previously determined for the exons of the normal human c-sis gene. Thus, the predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for normal human platelet-derived growth factor chain A.

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Year:  1984        PMID： 6740330     DOI： 10.1126/science.6740330

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  34 in total

1.  Platelet-derived growth factor activity and mRNA expression in healing vascular grafts in baboons. Association in vivo of platelet-derived growth factor mRNA and protein with cellular proliferation.

Authors:  M A Golden; Y P Au; T R Kirkman; J N Wilcox; E W Raines; R Ross; A W Clowes
Journal:  J Clin Invest       Date:  1991-02       Impact factor: 14.808

Review 2.  Platelet-derived growth factor: mechanism of action and possible in vivo function.

Authors:  C H Heldin; B Westermark
Journal:  Cell Regul       Date:  1990-07

3.  Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization.

Authors:  J N Wilcox; K M Smith; L T Williams; S M Schwartz; D Gordon
Journal:  J Clin Invest       Date:  1988-09       Impact factor: 14.808

4.  Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product.

Authors:  A Johnsson; C Betsholtz; K von der Helm; C H Heldin; B Westermark
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

5.  Isolation and sequencing of a cDNA clone homologous to the v-sis oncogene from human endothelial cells.

Authors:  B D Tong; S E Levine; M Jaye; G Ricca; W Drohan; T Maciag; T F Deuel
Journal:  Mol Cell Biol       Date:  1986-08       Impact factor: 4.272

6.  Regulation of expression of the c-sis proto-oncogene.

Authors:  L Ratner
Journal:  Nucleic Acids Res       Date:  1989-06-12       Impact factor: 16.971

7.  Identification of processing events in the synthesis of platelet-derived growth factor-like proteins by human osteosarcoma cells.

Authors:  D T Graves; A J Owen; S R Williams; H N Antoniades
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

8.  Sequences of the 5' portion of the human c-sis gene: characterization of the transcriptional promoter and regulation of expression of the protein product by 5' untranslated mRNA sequences.

Authors:  L Ratner; B Thielan; T Collins
Journal:  Nucleic Acids Res       Date:  1987-08-11       Impact factor: 16.971

9.  Human leukemia cells synthesize and secrete proteins related to platelet-derived growth factor.

Authors:  P Pantazis; L Lanfrancone; P G Pelicci; R Dalla-Favera; H N Antoniades
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

10.  Regulation of platelet-derived growth factor gene expression by transforming growth factor beta and phorbol ester in human leukemia cell lines.

Authors:  T P Mäkelä; R Alitalo; Y Paulsson; B Westermark; C H Heldin; K Alitalo
Journal:  Mol Cell Biol       Date:  1987-10       Impact factor: 4.272
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