Literature DB >> 6738709

A microchemical facility for the analysis and synthesis of genes and proteins.

M Hunkapiller, S Kent, M Caruthers, W Dreyer, J Firca, C Giffin, S Horvath, T Hunkapiller, P Tempst, L Hood.   

Abstract

A series of automated instruments that use state-of-the-art chemical methods has been developed for high-sensitivity protein sequencing, DNA synthesis and peptide synthesis. These instruments have been integrated into a centralized microchemical facility in order to promote their use for the study of a variety of biologically interesting problems. This facility has as one of its major functions the development of new chemistries and instrumentation for the structural analysis and synthesis of genes and proteins.

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Year:  1984        PMID: 6738709     DOI: 10.1038/310105a0

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  21 in total

1.  Controlling tumor-derived and vascular endothelial cell growth: role of the 4Ff2 cell surface antigen.

Authors:  M Papetti; I M Herman
Journal:  Am J Pathol       Date:  2001-07       Impact factor: 4.307

2.  The Drosophila melanogaster actin 5C gene uses two transcription initiation sites and three polyadenylation sites to express multiple mRNA species.

Authors:  B J Bond; N Davidson
Journal:  Mol Cell Biol       Date:  1986-06       Impact factor: 4.272

3.  Rational de novo gene synthesis by rapid polymerase chain assembly (PCA) and expression of endothelial protein-C and thrombin receptor genes.

Authors:  Tarlan G Mamedov; Nisha V Padhye; Hendrik Viljoen; Anuradha Subramanian
Journal:  J Biotechnol       Date:  2007-08-10       Impact factor: 3.307

Review 4.  Biological properties of single chemical-DNA adducts: a twenty year perspective.

Authors:  James C Delaney; John M Essigmann
Journal:  Chem Res Toxicol       Date:  2007-12-12       Impact factor: 3.739

5.  Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide.

Authors:  M A Levine; P M Smallwood; P T Moen; L J Helman; T G Ahn
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

6.  Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs.

Authors:  H K Fong; J B Hurley; R S Hopkins; R Miake-Lye; M S Johnson; R F Doolittle; M I Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

Review 7.  Molecular biology of type 1 (insulin-dependent) diabetes mellitus.

Authors:  A Lernmark
Journal:  Diabetologia       Date:  1985-04       Impact factor: 10.122

8.  High-sensitivity sequencing of large proteins: partial structure of the rapamycin-FKBP12 target.

Authors:  H Erdjument-Bromage; M Lui; D M Sabatini; S H Snyder; P Tempst
Journal:  Protein Sci       Date:  1994-12       Impact factor: 6.725

9.  Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin.

Authors:  J B Hurley; H K Fong; D B Teplow; W J Dreyer; M I Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

10.  Antimicrobial activity of synthetic magainin peptides and several analogues.

Authors:  M Zasloff; B Martin; H C Chen
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

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