Literature DB >> 6734703

Food does not effect in bioavailability of theophylline from Theolin Retard.

A P Sips, P M Edelbroek, S Kulstad, F A de Wolff, J H Dijkman.   

Abstract

The absorption of theophylline from a sustained release tablet preparation ( Theolin Retard 300 mg) was studied in 10 subjects both when fasting and immediately after a standardized breakfast. Intravenous aminophylline was used as the reference material. Food did not influence the absorption from Theolin Retard. The bioavailability was complete (93% after 30 h) both with and without food, and no difference was found in the time to peak of the plasma concentration curve (7 h), or the mean residence time (14 h). The absorption characteristics, with predominantly zero order kinetics, did not change with concomitant intake of breakfast.

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Year:  1984        PMID： 6734703     DOI： 10.1007/BF00548776

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  4 in total

1.  More sensitive high-pressure liquid-chromatographic determiantion of theophylline in serum.

Authors:  R F Adams; F L Vandemark; G J Schmidt
Journal:  Clin Chem       Date:  1976-11       Impact factor: 8.327

2.  Micro-scale method for theophylline in body fluids by reversed-phase, high-pressure liquid chromatography.

Authors:  J J Orcutt; P P Kozak; S A Gillman; L H Cummins
Journal:  Clin Chem       Date:  1977-03       Impact factor: 8.327

3.  Effect of food on the bioavailability and pattern of release of a sustained-release theophylline tablet.

Authors:  N H Leeds; P Gal; A A Purohit; J B Walter
Journal:  J Clin Pharmacol       Date:  1982-04       Impact factor: 3.126

4.  Relationship of formulation and dosing interval to fluctuation of serum theophylline concentration in children with chronic asthma.

Authors:  M Weinberger; L Hendeles; L Wong
Journal:  J Pediatr       Date:  1981-07       Impact factor: 4.406
  4 in total
  6 in total

1.  The effect of raising gastric pH with ranitidine on the absorption and elimination of theophylline from a sustained-release theophylline tablet.

Authors:  C J Betlach; A B Straughn; M C Meyer; M Bialer; V I Vashi; P Liebermann; M A González
Journal:  Pharm Res       Date:  1991-12       Impact factor: 4.200

2.  Circadian variation in theophylline absorption during chronic dosing with a slow release theophylline preparation and the effect of clock time of dosing.

Authors:  S H Jackson; A Johnston; R Woollard; S M Abrams; P Turner
Journal:  Br J Clin Pharmacol       Date:  1988-07       Impact factor: 4.335

Review 3.  The influence of nutrition on the systemic availability of drugs. Part I: Drug absorption.

Authors:  I Walter-Sack
Journal:  Klin Wochenschr       Date:  1987-10-01

Review 4.  Sustained release theophylline preparations. Practical recommendations for prescribing and therapeutic drug monitoring.

Authors:  A Glynn-Barnhart; M Hill; S J Szefler
Journal:  Drugs       Date:  1988-06       Impact factor: 9.546

5.  A floating controlled-release drug delivery system: in vitro-in vivo evaluation.

Authors:  S Desai; S Bolton
Journal:  Pharm Res       Date:  1993-09       Impact factor: 4.200

Review 6.  Food interactions with sustained-release theophylline preparations. A review.

Authors:  J H Jonkman
Journal:  Clin Pharmacokinet       Date:  1989-03       Impact factor: 6.447
  6 in total

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