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Literature DB >> 6732797

Amino acid sequence of rat epidermal thiol proteinase inhibitor.

K Takio, E Kominami, Y Bando, N Katunuma, K Titani.

Abstract

The complete amino acid sequence of rat epidermal thiol proteinase inhibitor was determined. The unique 103-residue sequence was derived by analysis of two peptides generated by limited proteolysis of the native inhibitor with Staphylococcus aureus V8 protease and of three cyanogen bromide fragments. The protein has a high degree of sequence homology to either rat liver or human leucocyte inhibitor but is not identical and may represent a new type of low molecular weight thiol proteinase inhibitors.

Entities: Chemical Gene Species

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Year: 1984 PMID： 6732797 DOI： 10.1016/0006-291x(84)90699-5

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

7 in total

1. Evolution of proteins of the cystatin superfamily.

Authors: N D Rawlings; A J Barrett
Journal: J Mol Evol Date: 1990-01 Impact factor: 2.395

2. Isolation and amino acid sequence of a cystatin-type cysteine proteinase inhibitor from bovine hoof.

Authors: H Tsushima; K Higashiyama; H Mine
Journal: Arch Dermatol Res Date: 1996-07 Impact factor: 3.017

3. Internally repeated sequences in ras gene products.

Authors: T Hiwasa
Journal: Biochem J Date: 1988-09-01 Impact factor: 3.857

4. Abnormal distribution of cathepsin proteinases and endogenous inhibitors (cystatins) in the hippocampus of patients with Alzheimer's disease, parkinsonism-dementia complex on Guam, and senile dementia and in the aged.

Authors: K Ii; H Ito; E Kominami; A Hirano
Journal: Virchows Arch A Pathol Anat Histopathol Date: 1993

Amino acid sequence of rat epidermal thiol proteinase inhibitor.

1. Evolution of proteins of the cystatin superfamily.

2. Isolation and amino acid sequence of a cystatin-type cysteine proteinase inhibitor from bovine hoof.

3. Internally repeated sequences in ras gene products.

4. Abnormal distribution of cathepsin proteinases and endogenous inhibitors (cystatins) in the hippocampus of patients with Alzheimer's disease, parkinsonism-dementia complex on Guam, and senile dementia and in the aged.

5. Potential proteolytic activity of human plasma fibronectin.

6. Abnormal increases of lysosomal cysteinine proteinases in rimmed vacuoles in the skeletal muscle.

7. Posttranslational processing and modification of cathepsins and cystatins.