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Literature DB >> 6731183

Effect of histamine on the hippocampal neurons in guinea-pigs.

Abstract

Histamine produced an excitatory effect on CA3 pyramidal cells in hippocampal slices of guinea-pigs. The amplitude of population spikes and EPSPs was augmented by histamine at concentrations of 10(-7) to 10(-6) M. Cimetidine but not pyrilamine prevented the stimulatory effect. The histamine effect was mimicked by dimaprit but not by 2-pyridylethylamine. It is concluded that histamine has a facilitatory influence on the hippocampal excitatory system via H2 receptor.

Entities: Chemical Gene Species

Mesh：

Substances：
Histamine

Year: 1984 PMID： 6731183 DOI： 10.1007/BF01973866

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

25 in total

1. Histamine synthesizing afferents to the hippocampal region.

Authors: G Barbin; M Garbarg; J C Schwartz; J Storm-Mathisen
Journal: J Neurochem Date: 1976-02 Impact factor: 5.372

2. Histamine microiontophoresis on identified hypothalamic neurons: 3 patterns of response in the ventromedial nucleus of the rat.

Authors: L P Renaud
Journal: Brain Res Date: 1976-10-15 Impact factor: 3.252

Effect of histamine on the hippocampal neurons in guinea-pigs.

1. Histamine synthesizing afferents to the hippocampal region.

2. Histamine microiontophoresis on identified hypothalamic neurons: 3 patterns of response in the ventromedial nucleus of the rat.

3. Noradrenergic stimulation of cyclic adenosine monophosphate in rat Purkinje neurons: an immunocytochemical study.

4. Histamine: action on single hypothalamic neurones.

5. The distribution of histamine H1-receptors in the rat brain: an autoradiographic study.

6. Monosynaptic connections between histamine-containing neurons and their various follower cells.

7. Histamine and metabolites: their effects and interactions with convulsants on brain stem neurones.

8. Histamine in isolated small nerve endings and synaptic vesicles of rat brain cortex.

9. Histamine modulates reactivity of hippocampal CA3 neurons to afferent stimulation in vitro.

10. Histamine hyperpolarizes hippocampal neurones in vitro.

1. Histamine may act through cyclic AMP on hippocampal neurones.